Cyanobufalins: Cardioactive Toxins from Cyanobacterial
Blooms
Version 3 2018-11-08, 21:45
Version 2 2018-10-28, 12:04
Version 1 2018-10-28, 12:03
Posted on 2018-11-08 - 21:45
Cyanobufalins A–C (1–3), a new series of cardiotoxic steroids, have
been discovered from cyanobacterial blooms in Buckeye Lake and Grand
Lake St. Marys in Ohio. Compounds 1–3 contain distinctive structural features, including geminal methyl
groups at C-4, a 7,8 double bond, and a C-16 chlorine substituent
that distinguish them from plant- or animal-derived congeners. Despite
these structural differences, the compounds are qualitatively identical
to bufalin in their cytotoxic profiles versus cell lines in tissue
culture and cardiac activity, as demonstrated in an impedance-based
cellular assay conducted with IPSC-derived cardiomyocytes. Cyanobufalins
are nonselectively toxic to human cells in the single-digit nanomolar
range and show stimulation of contractility in cardiomyocytes at sub-nanomolar
concentrations. The estimated combined concentration of 1–3 in the environment is in the same nanomolar
range, and consequently more precise quantitative analyses are recommended
along with more detailed cardiotoxicity studies. This is the first
time that cardioactive steroid toxins have been found associated with
microorganisms in an aquatic environment. Several factors point to
a microbial biosynthetic origin for the cyanobufalins.
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He, Haiyin; Bertin, Matthew J.; Wu, ShiBiao; G. Wahome, Paul; Beauchesne, Kevin R.; Youngs, Ross O.; et al. (2018). Cyanobufalins: Cardioactive Toxins from Cyanobacterial
Blooms. ACS Publications. Collection. https://doi.org/10.1021/acs.jnatprod.8b00736
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AUTHORS (10)
HH
Haiyin He
MB
Matthew J. Bertin
SW
ShiBiao Wu
PG
Paul G. Wahome
KB
Kevin R. Beauchesne
RY
Ross O. Youngs
PZ
Paul V. Zimba
PD
Peter D. R. Moeller
JS
Josep Sauri
GC
Guy T. Carter