Coupling of Carboxylic Acids with Ynamides and Subsequent Rearrangement for the Synthesis of Imides/Amides

Published on 2018-08-10T11:19:02Z (GMT) by
A coupling of carboxylic acids with ynamides and subsequent rearrangement for the synthesis of imides and amides is reported. The carboxylic acids could couple with ynamides to form α-acyloxyenamide followed by sulfonyl group migration and Mumm rearrangement to furnish the amides. Additionally, the products could be subjected to further rearrangement to deliver β-keto amides. This metal-free process represents an interesting method for chemical bonds cleavage and regeneration. Furthermore, divergent transformation of products were conducted to deliver an array of compounds.

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Shen, Yangyong; Li, Qi; Xu, Gang; Cui, Sunliang (2018): Coupling of Carboxylic Acids with Ynamides and Subsequent

Rearrangement for the Synthesis of Imides/Amides. ACS Publications. Collection.