Copper-Catalyzed Enantioselective Henry Reaction of
β,γ‑Unsaturated α‑Ketoesters with
Nitromethane in Water

Wang, Zhiyong

Copper-Catalyzed Enantioselective Henry Reaction of β,γ‑Unsaturated α‑Ketoesters with Nitromethane in Water

Posted on 2017-11-18 - 17:30

A highly enantioselective Henry reaction of β,γ-unsaturated α-ketoesters with nitromethane in water by virtue of chiral copper complexes has been developed. A series of unsaturated β-nitro-α-hydroxy esters bearing tetrasubstituted carbon stereocenters were obtained exclusively with high yields and excellent enantioselectivities. This method could avoid tedious anaerobic anhydrous manipulation and reduce the environmental pollution caused by organic solvents.

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Li, Yanan; Huang, Yekai; Gui, Yang; Sun, Jianan; Li, Jindong; Zha, Zhenggen; et al. (2017). Copper-Catalyzed Enantioselective Henry Reaction of β,γ‑Unsaturated α‑Ketoesters with Nitromethane in Water. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.7b03299

https://doi.org/10.1021/acs.orglett.7b03299

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