Conjugated Polymer Nanoparticles with Absorption beyond
1000 nm for NIR-II Fluorescence Imaging System Guided NIR-II Photothermal
Therapy
Posted on 2020-07-22 - 21:08
The second near-infrared
fluorescence imaging (NIR-II FI) guided
NIR-II photothermal therapy (PTT) possesses advantages for cancer
treatment because of its accurate diagnosis and enhanced therapeutic
effects for cancer. However, developing a conjugated polymer with
both excellent NIR-II fluorescence and NIR-II PTT properties encountered
many hindrances, including strong nonradiative decay, low solubility
in organic solution, and significant aggregation-caused quenching
(ACQ) effect. Herein, a conjugated polymer TTQ-2TC with optimized
absorption in NIR-II regions, good solubility in organic solvents,
and bright NIR-II FI signals is obtained through introducing the alkyl-side-chain-modified
bithiophene (2TC) as the electron-rich donor unit. The water-soluble
nanoparticle (TTQ-2TC NPs) prepared from the conjugated polymer TTQ-2TC
is used for precise NIR-II FI guided NIR-II PTT treatment. The in
vivo blood and tumor imaging and therapy results show that the TTQ-2TC
NPs possess high signal-to-background ratio (SBR) and perfect antitumor
efficacy by NIR-II PTT.
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Song, Xingwen; Lu, Xiaomei; Sun, Bo; Zhang, Hua; Sun, Pengfei; Miao, Han; et al. (2020). Conjugated Polymer Nanoparticles with Absorption beyond
1000 nm for NIR-II Fluorescence Imaging System Guided NIR-II Photothermal
Therapy. ACS Publications. Collection. https://doi.org/10.1021/acsapm.0c00637
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AUTHORS (8)
XS
Xingwen Song
XL
Xiaomei Lu
BS
Bo Sun
HZ
Hua Zhang
PS
Pengfei Sun
HM
Han Miao
QF
Quli Fan
WH
Wei Huang