Cobalt- and Iron-Catalyzed Redox Condensation of <i>o</i>‑Substituted Nitrobenzenes with Alkylamines: A Step- and Redox-Economical Synthesis of Diazaheterocycles

Published on 2017-11-14T19:36:37Z (GMT) by
A wide variety of functionalized 2-aryl benzimidazoles can be prepared by a solvent-free cobalt- or iron-catalyzed redox condensation of 2-nitroanilines and benzylamines. The cascade including benzylamine oxidation, nitro reduction, condensation, and aromatization occurs without any added reducing or oxidizing agent. The method can be extended to other alkylamines as reducing components or 2-nitrobenzamides as oxidizing components when using an iron/sulfur catalyst to afford various diazaheterocycles.

Cite this collection

Nguyen, Thanh Binh; Bescont, Julie Le; Ermolenko, Ludmila; Al-Mourabit, Ali (2017): Cobalt- and Iron-Catalyzed Redox Condensation of o‑Substituted Nitrobenzenes with Alkylamines: A Step- and Redox-Economical Synthesis of Diazaheterocycles. ACS Publications.

https://doi.org/10.1021/ol403064z

Retrieved: 22:20, Nov 24, 2017 (GMT)