Chemodivergent and Stereoselective Construction of gem-Difluoroallylic Amines from Masked Difluorodiazo Reagents

Ma, Jun-An

Chemodivergent and Stereoselective Construction of gem-Difluoroallylic Amines from Masked Difluorodiazo Reagents

Version 2 2019-09-12, 17:38

Version 1 2019-09-12, 17:36

Posted on 2019-09-12 - 17:38

We report a general and efficient approach to construct achiral and chiral gem-difluoroallylic amines from a masked difluorodiazo reagent (PhSO₂CF₂CHN₂) and readily available imines. This facile protocol takes advantage of the phenylsulfonyl and diazo moieties as efficient activating and directing groups to assist difluoroalkyl incorporation and facilitate the chemodivergent and stereoselective formation of gem-difluoroallylic amines.

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Zeng, Jun-Liang; Zhang, Yue; Zheng, Meng-Meng; Zhang, Zhi-Qi; Xue, Xiao-Song; Zhang, Fa-Guang; et al. (2019). Chemodivergent and Stereoselective Construction of gem-Difluoroallylic Amines from Masked Difluorodiazo Reagents. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.9b02989

https://doi.org/10.1021/acs.orglett.9b02989

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