Characterization
of Chalkophomycin, a Copper(II) Metallophore
with an Unprecedented Molecular Architecture
Posted on 2021-12-01 - 16:08
Metals play essential roles in life
by coordination with small
molecules, proteins, and nucleic acids. Although the coordination
of copper ions in many proteins and methanobactins is known, the coordination
chemistry of Cu(II) in natural products and their biological functions
remain underexplored. Herein, we report the discovery of a Cu(II)-binding
natural product, chalkophomycin (CHM, 1), from Streptomyces sp. CB00271, featuring an asymmetric square-coordination
system of a bidentate diazeniumdiolate and a conjugated 1H-pyrrole 1-oxide-oxazoline. The structure of 1 may inspire
the synthesis of Cu(II) chelators against neurodegenerative diseases
or Cu(II)-based antitumor therapeutics.
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Gong, Bang; Bai, Enhe; Feng, Xueqiong; Yi, Liwei; Wang, Yeji; Chen, Xin; et al. (2021). Characterization
of Chalkophomycin, a Copper(II) Metallophore
with an Unprecedented Molecular Architecture. ACS Publications. Collection. https://doi.org/10.1021/jacs.1c09311
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AUTHORS (9)
BG
Bang Gong
EB
Enhe Bai
XF
Xueqiong Feng
LY
Liwei Yi
YW
Yeji Wang
XC
Xin Chen
XZ
Xiangcheng Zhu
YD
Yanwen Duan
YH
Yong Huang