Cellular
Responses to Exposure to Outdoor Air from
the Chinese Spring Festival at the Air–Liquid Interface
Posted on 2019-07-17 - 12:09
The Spring Festival is the most important
holiday in China. During
this time, the levels of particulate matter (PM) as well as gaseous
copollutants significantly increase because of the widespread enjoyment
of fireworks. The expression patterns of microRNAs may serve as valuable
signatures of exposure to environmental constituents. We exposed macrophages
to the whole stream of outdoor air at the air–liquid interface
aiming at closely approximating the physiological conditions and the
inhalation situation in the lung. 58 miRNAs were up-regulated, and
68 miRNAs were down-regulated in the night of the New Year’s
Eve (exposure group E2N1) compared to filtered-air exposed control
cells. The target genes of the up-regulated miRNAs were enriched in
immunity- and inflammation-linked pathways, such as the TLR-NF-κB
pathway. Compared to the E2N1 group, 29 miRNAs were up-regulated,
and 23 miRNAs were down-regulated in the cells exposed to air from
the daytime of the Chinese New Year with higher concentrations of
particles, SO2, and nitrogen oxide. The target genes of
the up-regulated miRNAs were mostly enriched in apoptosis, adhesion,
and junction-related pathways. These results preliminarily unravel
part of the toxic mechanisms of air constituents and provide clues
for discovering the main drivers of air pollution-induced disorders.
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Ding, Jie; Guo, Jincheng; Wang, Liming; Chen, Yandong; Hu, Bin; Li, Yiye; et al. (2019). Cellular
Responses to Exposure to Outdoor Air from
the Chinese Spring Festival at the Air–Liquid Interface. ACS Publications. Collection. https://doi.org/10.1021/acs.est.9b00399
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AUTHORS (13)
JD
Jie Ding
JG
Jincheng Guo
LW
Liming Wang
YC
Yandong Chen
BH
Bin Hu
YL
Yiye Li
RH
Rujin Huang
JC
Junji Cao
YZ
Yuliang Zhao
MG
Marianne Geiser
QM
Qing Miao
YL
Ying Liu
CC
Chunying Chen