Cardiac-Referenced Leukocyte Telomere Length and Outcomes After Cardiovascular Surgery
Posted on 2019-06-12 - 08:29
Leukocyte telomere shortening reflects stress burdens and has been associated with cardiac events. However, the patient-specific clinical value of telomere assessment remains unknown. Moreover, telomere shortening cannot be inferred from a single telomere length assessment. The authors investigated and developed a novel strategy for gauging leukocyte telomere shortening using autologous cardiac atrial referencing. Using multitissue assessments from 163 patients who underwent cardiovascular surgery, we determined that the cardiac atrium-leukocyte telomere length difference predicted post-operative complexity. This constituted the first evidence that a single-time assessment of telomere dynamics might be salient to acute cardiac care.
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Yin, Hao; Akawi, Oula; Fox, Stephanie A.; Li, Fuyan; O'Neil, Caroline; Balint, Brittany; et al. (2019). Cardiac-Referenced Leukocyte Telomere Length and Outcomes After Cardiovascular Surgery. JACC: Basic to Translational Science. Collection. https://doi.org/10.25407/JACBTS.c.4538339.v1
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AUTHORS (15)
HY
Hao Yin
OA
Oula Akawi
SF
Stephanie A. Fox
FL
Fuyan Li
CO
Caroline O'Neil
BB
Brittany Balint
JA
John-Michael Arpino
AW
Alanna Watson
JW
Jorge Wong
LG
Linrui Guo
MQ
MacKenzie A. Quantz
AN
A. Dave Nagpal
BK
Bob Kiaii
MC
Michael W.A. Chu
JG
J. Geoffrey Pickering