Cardiac-Referenced Leukocyte Telomere Length and Outcomes After Cardiovascular Surgery

Published on 2019-06-12T08:29:55Z (GMT) by
Leukocyte telomere shortening reflects stress burdens and has been associated with cardiac events. However, the patient-specific clinical value of telomere assessment remains unknown. Moreover, telomere shortening cannot be inferred from a single telomere length assessment. The authors investigated and developed a novel strategy for gauging leukocyte telomere shortening using autologous cardiac atrial referencing. Using multitissue assessments from 163 patients who underwent cardiovascular surgery, we determined that the cardiac atrium-leukocyte telomere length difference predicted post-operative complexity. This constituted the first evidence that a single-time assessment of telomere dynamics might be salient to acute cardiac care.

Cite this collection

Yin, Hao; Akawi, Oula; Fox, Stephanie A.; Li, Fuyan; O'Neil, Caroline; Balint, Brittany; et al. (2019): Cardiac-Referenced Leukocyte Telomere Length and Outcomes After Cardiovascular Surgery. JACC: Basic to Translational Science. Collection.