Carboxylic Acid Directed C–H Arylation of Azulene

Xu, Jianwei

Carboxylic Acid Directed C–H Arylation of Azulene

Posted on 2020-06-17 - 16:09

The first example of directed C–H activation for azulene is reported. A variety of 2-arylazulenes are obtainable exclusively from 1-azulene carboxylic acids, with yields of up to 82%. Some heteroaryl groups such as pyridine and thiophene are also tolerated in the reaction. The efficacy of the reaction is found to be highly dependent on the conditions, with a phosphate base and a bulky carboxylic acid being key additives.

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Png, Zhuang Mao; Tam, Teck Lip Dexter; Xu, Jianwei (2020). Carboxylic Acid Directed C–H Arylation of Azulene. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.0c01576

https://doi.org/10.1021/acs.orglett.0c01576

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