Biocatalytic Synthesis of Non-Natural Monoterpene O‑Glycosides Exhibiting Superior Antibacterial and
Antinematodal Properties
Posted on 2019-05-29 - 08:13
A promiscuous Bacillus glycosyltransferase (YjiC)
was explored for the enzymatic synthesis of monoterpene O-glycosides in vitro and in vivo. YjiC converted seven monoterpenes
into 41 different sugar-conjugated novel glycoside derivatives. The
whole-cell biotransformation of the same set of monoterpenes exhibited
robust enzyme activity to synthesize O-glucosyl derivatives
from Escherichia coli. These newly
synthesized selected monoterpene-O-glucosyl derivatives
exhibited enhanced antibacterial activities against human pathogenic
bacteria and antinematodal activities against pine wood nematode Bursaphelenchus xylophilus.
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Bashyal, Puspalata; Pandey, Ramesh Prasad; Thapa, Samir Bahadur; Kang, Min-Kyoung; Kim, Chang-Jin; Sohng, Jae Kyung (2019). Biocatalytic Synthesis of Non-Natural Monoterpene O‑Glycosides Exhibiting Superior Antibacterial and
Antinematodal Properties. ACS Publications. Collection. https://doi.org/10.1021/acsomega.9b00535
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AUTHORS (6)
PB
Puspalata Bashyal
RP
Ramesh Prasad Pandey
ST
Samir Bahadur Thapa
MK
Min-Kyoung Kang
CK
Chang-Jin Kim
JS
Jae Kyung Sohng