BSA Nanoparticles Modified with N‑Acetylcysteine for Improving the Stability and Mucoadhesion of Curcumin in the Gastrointestinal Tract
Posted on 2019-08-13 - 00:29
A major obstacle to the clinical use of curcumin (CUR) is its reduced
bioavailability because of the drug’s hydrophobic nature, low
intestinal absorption, and rapid metabolism. In this study, a novel
oral drug delivery system was constructed for improving the stability
and enhancing mucoadhesion of CUR in the gastrointestinal (GI) tract.
First, CUR was encapsulated in the bovine serum albumin nanoparticles
(CUR-BSA-NPs). Then, N-acetyl cysteine (NAC)-modified
CUR-BSA-NPs (CUR-NBSA-NPs) were obtained. The average particle size
and zeta potential of CUR-NBSA-NPs were 251.6 nm and −30.66
mV, respectively; encapsulation efficiency and drug loading were 85.79
and 10.9%, respectively. CUR-NBSA-NPs exhibited a sustained release
property and prominently enhanced stability in simulated GI conditions.
Additionally, enhanced mucoadhesion of CUR-NBSA-NPs was also observed.
An MTT study showed that the CUR-NBSA-NPs were safe for oral administration.
Overall, NAC-modified BSA-NPs may potentially serve as an oral vehicle
for improving CUR stability in the GI tract and enhancing mucoadhesion.
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Zhang, Shanshan; Asghar, Sajid; Yu, Feng; Chen, Zhipeng; Hu, Ziyi; Ping, Qineng; et al. (2019). BSA Nanoparticles Modified with N‑Acetylcysteine for Improving the Stability and Mucoadhesion of Curcumin in the Gastrointestinal Tract. ACS Publications. Collection. https://doi.org/10.1021/acs.jafc.9b02272