Au(I)-Catalyzed Synthesis of Trisubstituted Indolizines from 2‑Propargyloxypyridines and Methyl Ketones

A new Au­(I)-catalyzed method for the preparation of trisubstituted indolizines from easily accessible 2‑propargyloxy-pyridines is reported. The reaction tolerates a wide range of functionality, allowing for diversity to be introduced in four distinct regions of the product (R, R¹, R², and Ar). The proposed mechanism proceeds via enol addition to an allenamide intermediate and explains the observed increase in yields when electron poor methyl ketones are utilized.