Antifungal Phenols from Woodfordia uniflora Collected
in Oman
Posted on 2020-07-08 - 16:07
Woodfordia uniflora is a flowering shrub unique
to the Dhofar region of Oman and is used locally as a sedative and
remedy for skin infection. However, no study to date has examined
the pharmacological properties of this plant, and studies regarding
phytochemicals present in W. uniflora are limited.
Herein, phytochemical screening of the extract of W. uniflora was performed using LC/MS. Three new phenolic compounds, (±)-woodfordiamycin
(1), woodfordic acid (2), and rhamnetin
3-O-(6″-galloyl)-β-d-glucopyranoside
(3), together with 16 known compounds 4–19, were isolated from the antifungal fraction of the extract.
The structures of the new compounds were established by NMR and HR-MS
data, and their absolute configurations were established using chemical
transformations, including Mosher’s method, comparison of experimental
and calculated electronic circular dichroism data, and gauge-including
atomic orbital NMR chemical shift calculations, followed by DP4+ analysis.
The isolated compounds (1–19) were
tested for antifungal activity against human fungal pathogens Cryptococcus neoformans and Candida albicans. Compounds (±)-1 and 8 showed antifungal
activity against C. neoformans, with the lowest minimum
inhibitory concentrations of 1.8–1.9 μM, which was ∼10-fold
lower than that of the currently available antifungal drug fluconazole,
while (±)-1, 8, and 19 showed antifungal activity against C. albicans.
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Yu, Jae Sik; Park, Minji; Pang, Changhyun; Rashan, Luay; Jung, Won Hee; Kim, Ki Hyun (2020). Antifungal Phenols from Woodfordia uniflora Collected
in Oman. ACS Publications. Collection. https://doi.org/10.1021/acs.jnatprod.0c00395
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AUTHORS (6)
JY
Jae Sik Yu
MP
Minji Park
CP
Changhyun Pang
LR
Luay Rashan
WJ
Won Hee Jung
KK
Ki Hyun Kim