Anchoring Ligand-Effect on Bright Contrast-Enhancing
Property of Hollow Mn3O4 Nanoparticle in T1‑Weighted Magnetic Resonance Imaging
Posted on 2018-06-13 - 13:56
Here,
we describe and conceptualize the influence of surface engineering
for hollow manganese oxide nanoparticles (HMONs)-based
contrast agents for magnetic resonance imaging (MRI). A systematic
study has been conducted for enhancing the relaxivities of HMONs by functionalizing their surface with various capping ligands having
different anchoring groups (carboxylate, alcohol, thiol, and amine).
Among all studied ligands, carboxylate-anchored ligands exhibit significant
increase in magnetization value upon surface capping of HMON. Contrary to the previous hypotheses based on the surface-Mn2+ ions accessibility to water molecules, we proposed surface
capping induced magnetization in HMON is responsible
for the enhanced relaxivity (r1) value.
Further, in vivo imaging efficacy of oleate-capped
HMON (OA-HMON) has been demonstrated in mouse brain.
This study provides an insightful understanding of contrast enhancement
and modulation by surface ligands on manganese oxide-based T1-contrast agents.
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Lee, Jihwan; Kumari, Nitee; Kim, Soo Min; Kim, Seonock; Jeon, Ki-Wan; Im, Geun Ho; et al. (2018). Anchoring Ligand-Effect on Bright Contrast-Enhancing
Property of Hollow Mn3O4 Nanoparticle in T1‑Weighted Magnetic Resonance Imaging. ACS Publications. Collection. https://doi.org/10.1021/acs.chemmater.8b00854
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AUTHORS (10)
JL
Jihwan Lee
NK
Nitee Kumari
SK
Soo Min Kim
SK
Seonock Kim
KJ
Ki-Wan Jeon
GI
Geun Ho Im
MJ
Moon-Sun Jang
WL
Won Jae Lee
JL
Jung Hee Lee
IL
In Su Lee