An Automated Bayesian Pipeline for Rapid Analysis of Single-Molecule Binding Data

Grünwald, David

An Automated Bayesian Pipeline for Rapid Analysis of Single-Molecule Binding Data

Posted on 2018-11-08 - 14:48 authored by Carlas Smith

We benchmarked the pipeline by measuring the binding properties of the well-studied, DNA-guided DNA endonuclease, TtAgo, an Argonaute protein from the Eubacterium Thermus thermophilus. We also used the pipeline to extend our understanding of TtAgo by measuring the protein's binding kinetics at physiological temperatures and for target DNAs containing multiple, adjacent binding sites. The data is posted here.

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Smith, Carlas; Jouravleva, Karina; Huisman, Maximiliaan; Jolly, Samson M; D Zamore, Phillip; Grünwald, David (2018). An Automated Bayesian Pipeline for Rapid Analysis of Single-Molecule Binding Data. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4294421.v1

https://doi.org/10.6084/m9.figshare.c.4294421.v1

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