Aminomethylation of Aryl Halides Using α‑Silylamines
Enabled by Ni/Photoredox Dual Catalysis
Posted on 2017-08-16 - 13:04
A protocol for the aminomethylation
of aryl halides using α-silylamines
via Ni/photoredox dual catalysis is described. The low oxidation potential
of these silylated species enables facile single electron transfer
(SET) oxidation of the amine followed by rapid desilylation. The resulting
α-amino radicals can be directly funneled into a nickel-mediated
cross-coupling cycle with aryl halides. The process accomplishes aminomethylation
under remarkably mild conditions and tolerates numerous aryl- and
heteroaryl halides with an array of functional groups.
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Remeur, Camille; Kelly, Christopher B.; Patel, Niki R.; Molander, Gary A. (2017). Aminomethylation of Aryl Halides Using α‑Silylamines
Enabled by Ni/Photoredox Dual Catalysis. ACS Publications. Collection. https://doi.org/10.1021/acscatal.7b01973
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AUTHORS (4)
CR
Camille Remeur
CK
Christopher B. Kelly
NP
Niki R. Patel
GM
Gary A. Molander