Aglycone Polyether Nanchangmycin and Its Homologues
Exhibit Apoptotic and Antiproliferative Activities against Cancer
Stem Cells
Version 2 2018-11-09, 21:43Version 2 2018-11-09, 21:43
Version 1 2018-10-18, 18:26Version 1 2018-10-18, 18:26
Posted on 2018-11-09 - 21:43
The potential of
the polyether salinomycin as an inhibitory agent
against cancer stem cells has attracted interest in this family of
compounds. In this study, we found that the aglycone polyether nanchangmycin
and its homologues show promising activities against breast cancer
stem cells as well as 38 other different types of cancer cells by in vitro assays. We found that aglycone polyethers caused
elevations in calcium levels, an accumulation of reactive oxygen species
and mitochondrial inner membrane permeability to H+ and
K+, resulting in the release of cytochrome c and apoptosis-inducing factor and the triggering of caspase-dependent
apoptosis. Our analyses also indicate that aglycone polyethers are
potent Wnt/β-catenin signaling inhibitors, blocking the Wnt
pathway and resulting in reduced cell survival. Notably, the key autophagy-related
proteins LC3A/B were also activated by aglycone polyether treatment.
Furthermore, nanchangmycin showed inhibitory effects toward somatic
tumors developed from MCF-7 paclitaxel-resistant breast cancer cells
injected into BALB/c mice. Our study not only provides promising candidates
for therapy against cancer stem cells but also provides the groundwork
for identifying stronger therapeutic agents among the natural polyether
compounds.
CITE THIS COLLECTION
DataCite
DataCiteDataCite
3 Biotech3 Biotech
3D Printing in Medicine3D Printing in Medicine
3D Research3D Research
3D-Printed Materials and Systems3D-Printed Materials and Systems
4OR4OR
AAPG BulletinAAPG Bulletin
AAPS OpenAAPS Open
AAPS PharmSciTechAAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität HamburgAbhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)ABI Technik (German)
Academic MedicineAcademic Medicine
Academic PediatricsAcademic Pediatrics
Academic PsychiatryAcademic Psychiatry
Academic QuestionsAcademic Questions
Academy of Management DiscoveriesAcademy of Management Discoveries
Academy of Management JournalAcademy of Management Journal
Academy of Management Learning and EducationAcademy of Management Learning and Education
Academy of Management PerspectivesAcademy of Management Perspectives
Academy of Management ProceedingsAcademy of Management Proceedings
Academy of Management ReviewAcademy of Management Review
Huang, Minjian; Liu, Bo; Liu, Ran; Li, Jian; Chen, Jilei; Jiang, Fenglei; et al. (2018). Aglycone Polyether Nanchangmycin and Its Homologues
Exhibit Apoptotic and Antiproliferative Activities against Cancer
Stem Cells. ACS Publications. Collection. https://doi.org/10.1021/acsptsci.8b00007