A Shared Regulatory Element Controls the Initiation of Tcf7 Expression During Early T Cell and Innate Lymphoid Cell Developments
The transcription factor TCF-1 (encoded by Tcf7) plays critical roles in several lineages of hematopoietic cells. In this study, we examined the molecular basis for Tcf7 regulation in T cells, innate lymphoid cells, and migratory conventional dendritic cells that we find express Tcf7. We identified a 1 kb regulatory element crucial for the initiation of Tcf7 expression in T cells and innate lymphoid cells, but dispensable for Tcf7 expression in Tcf7-expressing dendritic cells. Within this region, we identified a Notch binding site important for the initiation of Tcf7 expression in T cells but not in innate lymphoid cells. Our work establishes that the same regulatory element is used by distinct transcriptional controllers to initiate Tcf7 expression in T cells and ILCs.
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REFERENCES
- https://doi.org//10.1073/pnas.1110230108
- https://doi.org//10.1038/s41590-019-0445-7
- https://doi.org//10.1016/j.celrep.2017.06.071
- https://doi.org//10.1016/j.immuni.2018.01.012
- https://doi.org//10.1016/j.it.2019.10.006
- https://doi.org//10.1016/j.celrep.2016.09.025
- https://doi.org//10.1038/374070a0
- https://doi.org//10.1038/nature10279
- https://doi.org//10.1038/ni.3248
- https://doi.org//10.1038/ni977
- https://doi.org//10.1002/immu.200310005
- https://doi.org//10.1016/S1074-7613(03)00328-5
- https://doi.org//10.1038/s41467-017-00882-0
- https://doi.org//10.1038/s41590-018-0254-4
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AUTHORS (7)
CATEGORIES
- Transplantation Immunology
- Tumour Immunology
- Immunology not elsewhere classified
- Immunology
- Veterinary Immunology
- Animal Immunology
- Genetic Immunology
- Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies)
- Autoimmunity
- Cellular Immunology
- Humoural Immunology and Immunochemistry
- Immunogenetics (incl. Genetic Immunology)
- Innate Immunity