A Phosphorescent Rhenium(I) Tricarbonyl Polypyridine
Complex Appended with a Fructose Pendant That Exhibits Photocytotoxicity
and Enhanced Uptake by Breast Cancer Cells

Lo, Kenneth Kam-Wing

A Phosphorescent Rhenium(I) Tricarbonyl Polypyridine Complex Appended with a Fructose Pendant That Exhibits Photocytotoxicity and Enhanced Uptake by Breast Cancer Cells

Version 3 2018-07-11, 20:45

Version 2 2018-07-11, 20:13

Version 1 2016-02-18, 20:32

Posted on 2018-07-11 - 20:45

We demonstrated that the cytotoxicity of a phosphorescent rhenium(I) polypyridine complex with a fructose pendant was enhanced upon irradiation and the cellular uptake of the complex was mediated by fructose transporters and inhibited by unmodified fructose but was independent of glucose-specific transporters. This complex has been used to image breast cancer cells, where fructose transporters are overexpressed.

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Zhang, Kenneth Yin; Tso, Karson Ka-Shun; Louie, Man-Wai; Liu, Hua-Wei; Lo, Kenneth Kam-Wing (2016). A Phosphorescent Rhenium(I) Tricarbonyl Polypyridine Complex Appended with a Fructose Pendant That Exhibits Photocytotoxicity and Enhanced Uptake by Breast Cancer Cells. ACS Publications. Collection. https://doi.org/10.1021/om400612f

https://doi.org/10.1021/om400612f

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