A Biomimetic Approach to C-nor-D-homo-Steroids

Giannis, Athanassios

A Biomimetic Approach to C-nor-D-homo-Steroids

Posted on 2010-07-28 - 00:00

A biomimetic three-step transformation of classical “6-6-6-5”-steroids into their C-nor-D-homo-counterparts gives an easy and fast access to this highly important substructure of natural products, as it is found in cyclopamine, and nakiterpiosin. A novel reagent combination allows for the rearrangement even of 17-keto steroids with high endoselectivity. In several examples the broadness of this strategy is outlined.

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Heretsch, Philipp; Rabe, Sebastian; Giannis, Athanassios (2016). A Biomimetic Approach to C-nor-D-homo-Steroids. ACS Publications. Collection. https://doi.org/10.1021/ja103152k

https://doi.org/10.1021/ja103152k

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