2-D DIGE Analysis of Liver and Red Blood Cells Provides Further
Evidence for Oxidative Stress in Schizophrenia
Posted on 2007-01-05 - 00:00
The molecular disease mechanisms associated with schizophrenia remain largely unknown. Although
primarily considered a disorder of the brain, there is evidence of a peripheral component to
schizophrenia. In this study, we investigated liver tissue and red blood cells (RBC) from schizophrenia
patients and controls using 2-D DIGE proteomic analysis. Fourteen proteins were significantly altered
in liver samples from schizophrenia patients (n = 15) compared to healthy controls (n = 15). Analysis
of the schizophrenia RBC proteome revealed 8 proteins significantly altered in samples from
schizophrenia patients (13 antipsychotic-treated and 7 drug-naïve) compared to controls (n = 20). Six
of the altered proteins in the liver and four of the altered RBC proteins are related to oxidative stress.
These results corroborate our earlier findings obtained from post-mortem brain studies and substantiate
our hypothesis that metabolic alterations leading to oxidative stress are linked to the schizophrenia
disease process. Our results also suggest that at least some of the pathological processes associated
with the schizophrenia disease process can be traced in peripheral tissue. If peripheral cells can be
used as a disease surrogate, promising new investigative avenues could be explored.
Keywords: schizophrenia • oxidative stress • peripheral disease markers • proteomics
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Prabakaran, Sudhakaran; Wengenroth, Martina; Lockstone, Helen E.; Lilley, Kathryn; Leweke, F. Markus; Bahn, Sabine (2016). 2-D DIGE Analysis of Liver and Red Blood Cells Provides Further
Evidence for Oxidative Stress in Schizophrenia. ACS Publications. Collection. https://doi.org/10.1021/pr060308a
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AUTHORS (6)
SP
Sudhakaran Prabakaran
MW
Martina Wengenroth
HL
Helen E. Lockstone
KL
Kathryn Lilley
FL
F. Markus Leweke
SB
Sabine Bahn