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2025_HellaBolck_ccRCC_screens

Version 2 2025-02-21, 15:52
Version 1 2025-02-20, 22:23
Posted on 2025-02-21 - 15:52 authored by Filippo Piccinini

COLLECTION:

2025_HellaBolck_ccRCC_screens


Article:

Deep visual multi-omics profiling reveals mechanisms that underly cancer cell differentiation and aggressiveness in clear cell renal cell carcinoma

Hella A. Bolck, Ede Migh, Andras Kriston, Natalia H. Zajac, Susanne Kreutzer, Tiberiu Totu, Peter Leary, Ferenc Kovacs, Dorothea Rutishauser, Sybille Pfammatter, Jonas Grossmann, Cassandra Litchfield, Marija Buljan, Niels J. Rupp, Peter Horvath, Holger Moch

doi: https://doi.org/10.1101/2025.01.31.635927


DESCRIPTION OF THE FILES IN THE COLLECTION:

Files and images.


MAIN CONTACT:

Dr. Ede Migh, mighede@gmail.com


MAIN AFFILIATION:

Institute of Biochemistry, BRC, Hungary, Szeged


KEYWORDS:

Artificial intelligence (AI)

Digital pathology

Image analysis

Tumor biology


DESCRIPTION:

The dataset contains diagnostic hematoxylin and eosin (H&E)-stained sections from clear cell renal cell carcinoma (ccRCC). For each ccRCC case, we selected one to four representative formalin-fixed, paraffin-embedded tissue blocks and cut 10 µm sections using PEN MembraneSlides 1.0 . These were stained with H&E according to standard procedures. Slides were digitized scanning z-stacks with seven z-slices in 0.5 µm increments using a Hamamatsu C9600 scanner at ×40 optical magnification. The scanner resolution was 0.228 µm per pixel. 


COPYRIGHT:

* Copyright (c) 2025,

* BRC, Hungary, Szeged

* All rights reserved.

* This material is free; you can redistribute it and/or modify it under the terms of the CC BY 4.0.

* This material is distributed WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE

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FUNDING

This work was supported by grants from the Edoardo R., Giovanni, Giuseppe und Chiarina Sassella-Foundation and the Julius Müller Foundation.

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