Traver Hart

Publications

• How complete are current yeast and human protein-interaction networks?
• Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells
• Evaluation and design of genome-wide CRISPR/SpCas9 knockout screens
• MicroRNA regulation of molecular networks mapped by global MicroRNA, mRNA, and protein expression in activated T lymphocytes
• Finding the active genes in deep RNA-seq gene expression studies
• Systematic profiling of cellular phenotypes with spotted cell microarrays reveals mating-pheromone response genes
• Application of microdroplet PCR for large-scale targeted bisulfite sequencing
• High-throughput immunofluorescence microscopy using yeast spheroplast cell-based microarrays
• BAGEL: A computational framework for identifying essential genes from pooled library screens
• Natural Variation in Gene Expression Modulates the Severity of Mutant Phenotypes
• Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
• All for One, and One for All
• A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality
• Method for improved Illumina sequencing library preparation using NuGEN Ovation RNA-Seq System
• A map of human protein interactions derived from co-expression of human mRNAs and their orthologs
• Microdroplet PCR for highly multiplexed targeted bisulfite sequencing
• Extensive mapping of an innate immune network with CRISPR
• High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
• Human cell chips: Adapting DNA microarray spotting technology to cell-based imaging assays
• Defining CD4 T cell memory by the epigenetic landscape of CpG DNA methylation
• Measuring error rates in genomic perturbation screens: Gold standards for human functional genomics
• Systematic definition of protein constituents along the major polarization axis reveals an adaptive reuse of the polarization machinery in pheromone-treated budding yeast
• Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death
• A census of human soluble protein complexes
• PICKLES: The database of pooled in-vitro CRISPR knockout library essentiality screens
• BAGEL: A computational framework for identifying essential genes from pooled library screens.
• Systematic discovery and classification of human cell line essential genes
• Scaling up the systematic hunt for mammalian genetic interactions