Tim Stinear

Research Fellow
Australia

Publications

  • Proteomic characterization of a natural host-pathogen interaction: Repertoire of in vivo expressed bacterial and host surface-associated proteins DOI: 10.1021/pr5010086
  • Identification of the Mycobacterium ulcerans Protein MUL_3720 as a Promising Target for the Development of a Diagnostic Test for Buruli Ulcer DOI: 10.1371/journal.pntd.0003477
  • The evolution of vancomycin intermediate Staphylococcus aureus (VISA) and heterogenous-VISA DOI: 10.1016/j.meegid.2013.03.047
  • Population genetics and the evolution of virulence in Staphylococcus aureus DOI: 10.1016/j.meegid.2013.04.026
  • Mycobacterial toxin induces analgesia in Buruli ulcer by targeting the angiotensin pathways DOI: 10.1016/j.cell.2014.04.040
  • Molecular epidemiology of enterococcal bacteremia in Australia DOI: 10.1128/JCM.03286-13
  • Investigating the Role of Free-living Amoebae as a Reservoir for Mycobacterium ulcerans DOI: 10.1371/journal.pntd.0003148
  • Hyperexpression of -hemolysin explains enhanced virulence of sequence type 93 community-associated methicillin-resistant Staphylococcus aureus DOI: 10.1186/1471-2180-14-31
  • Emergence of a ribotype 244 strain of clostridium difficile associated with severe disease and related to the epidemic ribotype 027 strain DOI: 10.1093/cid/ciu203
  • Corrigendum to A glimpse into the past and predictions for the future: The molecular evolution of the tuberculosis agent [Mol Microbiol 93 (2014) 835-852] DOI: 10.1111/mmi.12806
  • Analysis of the Vaccine Potential of Plasmid DNA Encoding Nine Mycolactone Polyketide Synthase Domains in Mycobacterium ulcerans Infected Mice DOI: 10.1371/journal.pntd.0002604
  • Adaptive change inferred from genomic population analysis of the ST93 epidemic clone of community-associated methicillin-resistant Staphylococcus aureus DOI: 10.1093/gbe/evu022
  • A glimpse into the past and predictions for the future: The molecular evolution of the tuberculosis agent DOI: 10.1111/mmi.12720
  • The RpoB H148Y rifampicin resistance mutation and an active stringent response reduce virulence and increase resistance to innate immune responses in staphylococcus aureus DOI: 10.1093/infdis/jis772
  • The Cell Wall-Associated Mycolactone Polyketide Synthases Are Necessary but Not Sufficient for Mycolactone Biosynthesis DOI: 10.1371/journal.pone.0070520
  • Reply to "internet-based solutions for analysis of next-generation sequence data" DOI: 10.1128/JCM.01393-13
  • Regulation of Mycolactone, the Mycobacterium ulcerans Toxin, Depends on Nutrient Source DOI: 10.1371/journal.pntd.0002502
  • Outbreak investigation using high-throughput genome sequencing within a diagnostic microbiology laboratory DOI: 10.1128/JCM.03332-12
  • Genomic insights to control the emergence of vancomycin-resistant enterococci DOI: 10.1128/mBio.00412-13
  • Genomic analysis of teicoplanin resistance emerging during treatment of vanB vancomycin-resistant Enterococcus faecium infections in solid organ transplant recipients including donor-derived cases DOI: 10.1093/jac/dkt130
  • Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis DOI: 10.1038/ng.2517
  • Functional genomics of staphylococcus aureus DOI: 10.1093/bfgp/elt006
  • Decreased vancomycin susceptibility in Staphylococcus aureus caused by IS256 tempering of walKR expression DOI: 10.1128/AAC.00279-13
  • Complete genome sequence of the frog pathogen Mycobacterium ulcerans ecovar Liflandii DOI: 10.1128/JB.02132-12
  • Comparative analysis of the complete genome of an epidemic hospital sequence type 203 clone of vancomycin-resistant Enterococcus faecium DOI: 10.1186/1471-2164-14-595
  • Analysis of the small RNA transcriptional response in multidrug-resistant staphylococcus aureus after antimicrobial exposure DOI: 10.1128/AAC.00263-13
  • The molecular epidemiology of the highly virulent st93 australian community staphylococcus aureus strain DOI: 10.1371/journal.pone.0043037
  • The lipoprotein LpqW is essential for the mannosylation of periplasmic glycolipids in corynebacteria DOI: 10.1074/jbc.M112.373415
  • The genome, evolution and diversity of Mycobacterium ulcerans DOI: 10.1016/j.meegid.2012.01.018
  • Rapid and sensitive detection of Mycobacterium ulcerans by use of a loop-mediated isothermal amplification test DOI: 10.1128/JCM.06460-11
  • On the origin of Mycobacterium ulcerans, the causative agent of Buruli ulcer DOI: 10.1186/1471-2164-13-258
  • The dominant Australian community-acquired methicillin-resistant Staphylococcus aureus clone ST93-IV [2B] is highly virulent and genetically distinct DOI: 10.1371/journal.pone.0025887
  • Mycobacterium ulcerans DNA not detected in Faecal samples from Buruli ulcer patients: Results of a pilot study DOI: 10.1371/journal.pone.0019611
  • Evolution of multidrug resistance during staphylococcus aureus infection involves mutation of the essential two component regulator WalKR DOI: 10.1371/journal.ppat.1002359
  • Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection DOI: 10.1371/journal.ppat.1000944
  • Single nucleotide polymorphism typing of mycobacterium ulcerans reveals focal transmission of buruli ulcer in a highly endemic Region of Ghana DOI: 10.1371/journal.pntd.0000751
  • Serological evaluation of mycobacterium ulcerans Antigens identified by comparative genomics DOI: 10.1371/journal.pntd.0000872
  • Regulation of the 18-kDa heat shock protein in Mycobacterium ulcerans: An alpha-crystallin orthologue that promotes biofilm formation DOI: 10.1111/j.1365-2958.2010.07401.x
  • Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: Resistance mechanisms, laboratory detection, and clinical implications DOI: 10.1128/CMR.00042-09
  • Mycobacterium ulcerans and other Mycolactone-producing mycobacteria should be considered a single species DOI: 10.1371/journal.pntd.0000663
  • Complete genome sequence of Staphylococcus aureus strain JKD6159, a unique Australian clone of ST93-IV community methicillin-resistant Staphylococcus aureus DOI: 10.1128/JB.00878-10
  • Complete genome sequence of Staphylococcus aureus strain JKD6008, an ST239 clone of methicillin-resistant Staphylococcus aureus with intermediate-level vancomycin resistance DOI: 10.1128/JB.00951-10
  • A sustained hospital outbreak of vancomycin-resistant Enterococcus faecium bacteremia due to emergence of vanB E. faecium sequence type 203 DOI: 10.1086/656319
  • A major role for mammals in the ecology of Mycobacterium ulcerans DOI: 10.1371/journal.pntd.0000791
  • A diagnostic PCR assay for the detection of an Australian epidemic strain of Pseudomonas aeruginosa DOI: 10.1186/1476-0711-9-18
  • Transfer, stable maintenance and expression of the mycolactone polyketide megasynthase mls genes in a recombination-impaired Mycobacterium marinum DOI: 10.1099/mic.0.027029-0
  • Pathogenicity in the tubercle bacillus: Molecular and evolutionary determinants DOI: 10.1002/bies.200800191
  • Mycolactone gene expression is controlled by strong SigA-like promoters with utility in studies of Mycobacterium ulcerans and buruli ulcer DOI: 10.1371/journal.pntd.0000553
  • Lack of insertional-deletional polymorphism in a collection of Mycobacterium ulcerans isolates from Ghanaian Buruli ulcer patients DOI: 10.1128/JCM.00760-09
  • Buruli ulcer: Reductive evolution enhances pathogenicity of Mycobacterium ulcerans DOI: 10.1038/nrmicro2077
  • Mycolactones: Immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria DOI: 10.1039/b803101k
  • Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis (Genome Research (2008) 18 (729-741)) EID: 2-s2.0-53549111891
  • Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis DOI: 10.1101/gr.075069.107
  • Genomic analysis reveals a point mutation in the two-component sensor gene graS that leads to intermediate vancomycin resistance in clinical Staphylococcus aureus DOI: 10.1128/AAC.01613-07
  • First report of a mycolactone-producing Mycobacterium infection in fish agriculture in Belgium DOI: 10.1111/j.1574-6968.2008.01264.x
  • First isolation of Mycobacterium ulcerans from an aquatic environment: The end of a 60-year search? DOI: 10.1371/journal.pntd.0000216
  • Evaluation of VNTR typing for the identification of Mycobacterium ulcerans in environmental samples from Victoria, Australia DOI: 10.1111/j.1574-6968.2008.01328.x
  • Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia DOI: 10.1186/1471-2180-8-39
  • Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones DOI: 10.1186/1471-2164-9-462
  • Comprehensive proteome analysis of Mycobacterium ulcerans and quantitative comparison of mycolactone biosynthesis DOI: 10.1002/pmic.200701018
  • Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer DOI: 10.1101/gr.5942807
  • Ongoing genome reduction in Mycobacterium ulcerans EID: 2-s2.0-34447271719
  • Mycobacterium ulcerans in mosquitoes captured during outbreak of Buruli ulcer, southeastern Australia EID: 2-s2.0-36249021612
  • From marinum to ulcerans: A mycobacterial human pathogen emerges EID: 2-s2.0-35449006169
  • First case of Mycobacterium ulcerans disease (Bairnsdale or Buruli ulcer) acquired in New South Wales EID: 2-s2.0-33846620649
  • Evolution of two distinct phylogenetic lineages of the emerging human pathogen Mycobacterium ulcerans DOI: 10.1186/1471-2148-7-177
  • Evolution of Mycobacterium ulcerans and other mycolactone-producing mycobacteria from a common Mycobacterium marinum progenitor DOI: 10.1128/JB.01442-06
  • Development and application of two multiplex real-time PCR assays for the detection of Mycobacterium ulcerans in clinical and environmental samples DOI: 10.1128/AEM.02971-06
  • Analysis of the Mycobacterium ulcerans genome sequence reveals new loci for variable number tandem repeats (VNTR) typing DOI: 10.1099/mic.0.2006/004564-0
  • A novel mycolactone toxin obtained by biosynthetic engineering DOI: 10.1002/cbic.200700411
  • Isolates with low-level vancomycin resistance associated with persistent methicillin-resistant Staphylococcus aureus bacteremia DOI: 10.1128/AAC.00422-06
  • Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry DOI: 10.1039/b506835e
  • Functional analysis and annotation of the virulence plasmid pMUM001 from Mycobacterium ulcerans DOI: 10.1099/mic.0.27674-0
  • Erratum: Buruli ulcer (M. ulcerans infection): New insights, new hope for disease control (PLoS Medicine 2:4 DOI: 10.1371/journal.pmed.0020108) DOI: 10.1371/journal.pmed.0020173
  • Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans DOI: 10.1128/JB.187.5.1668-1676.2005
  • Buruli ulcer (M. ulcerans infection): New insights, new hope for disease control DOI: 10.1371/journal.pmed.0020108
  • A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase DOI: 10.1002/cbic.200400339
  • Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans DOI: 10.1073/pnas.0305877101
  • Aquatic Plants Stimulate the Growth of and Biofilm Formation by Mycobacterium ulcerans in Axenic Culture and Harbor These Bacteria in the Environment DOI: 10.1128/AEM.70.2.1097-1103.2004
  • Subtractive Hybridization Reveals a Type I Polyketide Synthase Locus Specific to Mycobacterium ulcerans DOI: 10.1128/JB.185.23.6870-6882.2003
  • Mycolactones and Mycobacterium ulcerans disease DOI: 10.1016/S0140-6736(03)14417-0
  • Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans EID: 2-s2.0-0345393085
  • Enterococcal vanB resistance locus in anaerobic bacteria in human faeces DOI: 10.1016/S0140-6736(00)04206-9
  • Identification of Mycobacterium ulcerans in the environment from regions in southeast Australia in which it is endemic with sequence capture-PCR DOI: 10.1128/AEM.66.8.3206-3213.2000
  • Comparative genetic analysis of mycobacterium ulcerans and Mycobacterium marinum reveals evidence of recent divergence DOI: 10.1128/JB.182.22.6322-6330.2000
  • A simple PCR method for rapid genotype analysis of Mycobacterium ulcerans EID: 2-s2.0-0034004771
  • Mycobacterium ulcerans - A mini-review EID: 2-s2.0-0032832883
  • Identification and characterization of IS2404 and IS2606: Two distinct repeated sequences for detection of Mycobacterium ulcerans by PCR EID: 2-s2.0-0032998963
  • Sensitive and rapid detection of viable Giardia cysts and Cryptosporidium parvum oocysts in large-volume water samples with wound fiberglass cartridge filters and reverse transcription-PCR EID: 2-s2.0-0031834279
  • Erratum: Sensitive and rapid detection of viable Giardia cysts and Cryptosporidium parvum oocysts in large-volume water samples with wound fiberglass cartridge filters and reverse transcription-PCR (Applied and Environmental Microbiology (1998) 64:5 (1743-1749)) EID: 2-s2.0-0031765835
  • Erratum: Detection of a single viable Cryptosporidium parvum oocyst in environmental water concentrates by reverse transcription-PCR (Applied and Environmental Microbiology 62:9 (3386)) EID: 2-s2.0-0030952238
  • Detection of Mycobacterium ulcerans in environmental samples during an outbreak of ulcerative disease EID: 2-s2.0-0030821126
  • Detection of pathogenic Yersinia enterocolitica in environmental waters by PCR EID: 2-s2.0-0029932907
  • Detection of a single viable Cryptosporidium parvum oocyst in environmental water concentrates by reverse transcription-PCR EID: 2-s2.0-0029812687