Stephen Curry

Professor of Structural Biology
Imperial College London

Publications

  • Structures of the compact helical core domains of feline calicivirus and murine norovirus VPg proteins DOI: 10.1128/JVI.03151-12
  • Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human la protein DOI: 10.1093/nar/gkr890
  • Defining the roles and interactions of PTB DOI: 10.1042/BST20120044
  • Structure of a murine norovirus NS6 protease-product complex revealed by adventitious crystallisation DOI: 10.1371/journal.pone.0038723
  • Activation of picornaviral IRESs by PTB shows differential dependence on each PTB RNA-binding domain DOI: 10.1261/rna.2549411
  • Crystallographic analysis of polypyrimidine tract-binding protein-raver1 interactions involved in regulation of alternative splicing DOI: 10.1016/j.str.2011.09.020
  • Crystallographic analysis reveals the structural basis of the high-affinity binding of Iophenoxic acid to Human Serum Albumin DOI: 10.1186/1472-6807-11-18
  • Evolutionary analysis of serotype A foot-and-mouth disease viruses circulating in Pakistan and Afghanistan during 2002-2009 DOI: 10.1099/vir.0.035626-0
  • Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin DOI: 10.1016/j.jsb.2010.10.004
  • Structural insights into differences in drug-binding selectivity between two forms of human α1-acid glycoprotein genetic variants, the A and F1*S forms DOI: 10.1074/jbc.M110.208926
  • Effect of foot-and-mouth disease virus capsid precursor protein and 3C protease expression on bovine herpesvirus 1 replication DOI: 10.1007/s00705-010-0648-6
  • Foot-and-mouth disease virus 2C is a hexameric AAA+ protein with a coordinated ATP hydrolysis mechanism DOI: 10.1074/jbc.M110.129940
  • Insights into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate DOI: 10.1016/j.jmb.2009.10.048
  • Detailed insights from microarray and crystallographic studies into carbohydrate recognition by microneme protein 1 (MIC1) of Toxoplasma gondii DOI: 10.1002/pro.204
  • Getting to the end of RNA: Structural analysis of protein recognition of 5′ and 3′ termini DOI: 10.1016/j.bbagrm.2009.07.003
  • Journal club. A crystallographer takes a jaunt into immunology.
  • Lessons from the crystallographic analysis of small molecule binding to human serum albumin DOI: 10.2133/dmpk.24.342
  • O 2 binding properties of human serum albumin quadruple mutant complexed iron protoporphyrin ix with axial his-186 coordination DOI: 10.1246/cl.2009.776
  • Polypyrimidine Tract Binding Protein Stabilizes the Encephalomyocarditis Virus IRES Structure via Binding Multiple Sites in a Unique Orientation DOI: 10.1016/j.molcel.2009.04.015
  • The role of an amino acid triad at the entrance of the heme pocket in human serum albumin for O2 and CO binding to iron protoporphyrin IX DOI: 10.1039/b909794e
  • Widen the channels of communication with society DOI: 10.1038/458702d
  • Crystallographic Analysis of Human Serum Albumin Complexed with 4Z,15E-Bilirubin-IXα DOI: 10.1016/j.jmb.2008.06.016
  • NMR assignment of the N-terminal region of human La free and in complex with RNA DOI: 10.1007/s12104-008-9097-5
  • Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3′ Ends by the Human La Protein DOI: 10.1016/j.str.2008.02.021
  • A continuous assay for foot-and-mouth disease virus 3C protease activity DOI: 10.1016/j.ab.2007.05.026
  • Foot-and-mouth disease virus 3C protease: Recent structural and functional insights into an antiviral target DOI: 10.1016/j.biocel.2006.07.006
  • Genetic engineering of the heme pocket in human serum albumin: Modulation of O2 binding of iron protoporphyrin IX by variation of distal amino acids DOI: 10.1021/ja074179q
  • Structural analysis of foot-and-mouth disease virus 3C protease: A viable target for antiviral drugs? DOI: 10.1042/BST0350594
  • Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the β-ribbon in proteolysis DOI: 10.1128/JVI.01587-06
  • Structural insights into the transcriptional and translational roles of Ebp1 DOI: 10.1038/sj.emboj.7601817
  • A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domain DOI: 10.1038/nsmb1137
  • A terminal affair: 3′-end recognition by the human La protein DOI: 10.1016/j.tibs.2006.04.008
  • Conformation of Polypyrimidine Tract Binding Protein in Solution DOI: 10.1016/j.str.2006.04.005
  • Location of High and Low Affinity Fatty Acid Binding Sites on Human Serum Albumin Revealed by NMR Drug-competition Analysis DOI: 10.1016/j.jmb.2006.06.028
  • Photosensitized reduction of water to hydrogen using human serum albumin complexed with zinc-protoporphyrin IX DOI: 10.1021/ja0656806
  • Role of RNA structure and RNA binding activity of foot-and-mouth disease virus 3C protein in VPg uridylylation and virus replication DOI: 10.1128/JVI.00561-06
  • Crystal structure of foot-and-mouth disease virus 3C protease: New insights into catalytic mechanism and cleavage specificity DOI: 10.1074/jbc.M413254200
  • Crystallization of foot-and-mouth disease virus 3C protease: Surface mutagenesis and a novel crystal-optimization strategy DOI: 10.1107/S0907444905007924
  • Locating high-affinity fatty acid-binding sites on albumin by x-ray crystallography and NMR spectroscopy DOI: 10.1073/pnas.0506440102
  • O2 and CO binding properties of artificial hemoproteins formed by complexing iron protoporphyrin IX with human serum albumin mutants DOI: 10.1021/ja054819u
  • Structural Basis of the Drug-binding Specificity of Human Serum Albumin DOI: 10.1016/j.jmb.2005.07.075
  • Structure of Foot-and-mouth disease virus serotype A1061 alone and complexed with oligosaccharide receptor: Receptor conservation in the face of antigenic variation DOI: 10.1099/vir.0.80730-0
  • The extraordinary ligand binding properties of human serum albumin DOI: 10.1080/15216540500404093
  • The polypyrimidine tract binding protein is a monomer DOI: 10.1261/rna.2214405
  • Dioxygenation of human serum albumin having a prosthetic heme group in a tailor-made heme pocket DOI: 10.1021/ja046022t
  • Letter to the editor: Resonance assignment and secondary structure of the La motif [27] DOI: 10.1023/B:JNMR.0000032556.32985.89
  • Plasma albumin as a fatty acid carrier DOI: 10.1016/S1569-2558(03)33003-6
  • Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein DOI: 10.1038/nsmb747
  • Structure and RNA interactions of the N-terminal RRM domains of PTB DOI: 10.1016/j.str.2004.07.008
  • Crystal structural analysis of human serum albumin complexed with hemin and fatty acid DOI: 10.1186/1472-6807-3-1
  • Resonance assignment and secondary structure of an N-terminal fragment of the human La protein [4] DOI: 10.1023/A:1024741228802
  • Solution structure and RNA interactions of the RNA recognition motif from eukaryotic translation initiation factor 4B DOI: 10.1021/bi034506g
  • Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia DOI: 10.1073/pnas.1137188100
  • Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element DOI: 10.1016/S0969-2126(03)00121-7
  • Beyond Expansion: Structural Studies on the Transport Roles of Human Serum Albumin DOI: 10.1111/j.1423-0410.2002.tb05326.x
  • Chemical shift mapping of RNA interactions with the polypyrimidine tract binding protein
  • Interactions of very long-chain saturated fatty acids with serum albumin DOI: 10.1194/jlr.M200041-JLR200
  • Probing the structure of the warfarin-binding site on human serum albumin using site-directed mutagenesis DOI: 10.1002/prot.10068
  • Resonance assignment and secondary structure determination of a C-terminal fragment of the Lupus Autoantigen (La) protein containing a putative RNA recognition motif (RRM) [10] DOI: 10.1023/A:1014928117895
  • Resonance assignment and topology of the 2H, 13C, 15N labelled 29 kDa N-terminal fragment of the polypyrimidine tract binding protein (PTB) [6] DOI: 10.1023/A:1020635912814
  • Crystal structure analysis of warfarin binding to human serum albumin. Anatomy of drug site I DOI: 10.1074/jbc.M100575200
  • Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids DOI: 10.1006/jmbi.2000.5208
  • Binding of the general anesthetics propofol and halothane to human serum albumin: High resolution crystal structures DOI: 10.1074/jbc.M005460200
  • Crystallographic analysis reveals common modes of binding of medium and long-chain fatty acids to human serum albumin DOI: 10.1006/jmbi.2000.4158
  • Molecular tectonic model of virus structural transitions: The putative cell entry states of poliovirus DOI: 10.1128/JVI.74.3.1342-1354.2000
  • Structure of tandem RNA recognition motifs from polypyrimidine tract binding protein reveals novel features of the RRM fold
  • Fatty acid binding to human serum albumin: New insights from crystallographic studies DOI: 10.1016/S1388-1981(99)00148-1
  • Letter to the editor: Resonance assignment and topology of a 22 kDa C-terminal fragment of the polypyrimidine tract binding protein (PTB) containing two RNA binding domains DOI: 10.1023/A:1008384112897
  • Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites DOI: 10.1038/1869
  • Titration calculations of foot-and-mouth disease virus capsids and their stabilities as a function of pH DOI: 10.1006/jmbi.1997.1418
  • Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: The structure of empty capsids of foot-and-mouth disease virus
  • Structural studies of poliovirus mutants that overcome receptor defects DOI: 10.1038/nsb0897-666
  • Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity
  • The poliovirus 135S particle is infectious
  • Structural comparison of two strains of foot-and-mouth disease virus subtype O1 and a laboratory antigenic variant, G67
  • Viral RNA modulates the acid sensitivity of foot-and-mouth disease virus capsids
  • The structure and antigenicity of a type C foot-and-mouth disease virus
  • The structure of an immunodominant loop on foot and mouth disease virus, serotype O1, determined under reducing conditions.
  • Structure of a major immunogenic site on foot-and-mouth disease virus
  • Crystallization and preliminary X-ray analysis of three serotypes of foot-and-mouth disease virus DOI: 10.1016/0022-2836(92)90332-E
  • Mapping the polarity profiles of general anesthetic target sites using n-alkane-(α,ω)-diols
  • Probing the molecular dimensions of general anaesthetic target sites in tadpoles (Xenopus laevis) and model systems using cycloalcohols
  • Effects of general anesthetics on the bacterial luciferase enzyme from vibrio harveyi: an anesthetic target site with differential sensitivity
  • Beyond Expansion: Structural Studies on the Transport Roles of Human Serum Albumin DOI: http://dx.doi.org/10.1111/j.1423-0410.2002.tb05326.x
  • By the people, for the people DOI: http://dx.doi.org/10.1016/s0262-4079(12)61617-0

Stephen's public data