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Siouxsie Wiles

Senior Lecturer

New Zealand

Dr Siouxsie Wiles studied medical microbiology at the University of Edinburgh, UK and then did a PhD in microbiology at the Centre for Ecology and Hydrology in Oxford. She spent several years working at Imperial College London where her research won the inaugural UK National Centre for the Replacement, Refinement and Reduction of Animals in Research prize. In 2009, Siouxsie was awarded a Sir Charles Hercus Fellowship from the Health Research Council of New Zealand and relocated to the University of Auckland, where she is now a Senior Lecturer and head up the Bioluminescent Superbugs Lab. Siouxsie also has a keen interest in demystifying science for the public; she is a tweeter, blogger, podcaster, radio science commentator, artist and curator. Siouxsie has won a hat-trick of New Zealand science communication prizes for her efforts, starting with the New Zealand Association of Scientists Science Communicator award in 2012 and followed by the Prime Minister’s Science Media Prize and Royal Society of New Zealand Callaghan Medal in 2013.

Publications

  • Rapid in vivo assessment of drug efficacy against Mycobacterium tuberculosis using an improved firefly luciferase. DOI: 10.1093/jac/dkt155
  • Population-based incidence and comparative demographics of community-associated and healthcare-associated Escherichia coli bloodstream infection in Auckland, New Zealand, 2005 -- 2011. DOI: 10.1186/1471-2334-13-385
  • Galleria mellonella larvae as an infection model for group A streptococcus. DOI: 10.4161/viru.24930
  • Clinical and molecular correlates of virulence in Escherichia coli causing bloodstream infection following transrectal ultrasound-guided (TRUS) prostate biopsy. PMID: 23833184
  • Xentry, a new class of cell-penetrating peptide uniquely equipped for delivery of drugs. DOI: 10.1038/srep01661
  • Setting up and monitoring an infection of Dictyostelium discoideum with mycobacteria. DOI: 10.1007/978-1-62703-302-2_22
  • Inactivation of the CovR/S virulence regulator impairs infection in an improved murine model of Streptococcus pyogenes naso-pharyngeal infection. DOI: 10.1371/journal.pone.0061655
  • Effects of ascent to high altitude on human antimycobacterial immunity. DOI: 10.1371/journal.pone.0074220
  • Characterization of a Mouse-Adapted Staphylococcus aureus Strain. DOI: 10.1371/journal.pone.0071142
  • Molecular Imaging in TB: From the Bench to the Clinic DOI: 10.5772/30595
  • Rapid measurement of antituberculosis drug activity in vitro and in macrophages using bioluminescence DOI: 10.1093/jac/dkr472
  • A new in vivo model to test anti-tuberculosis drugs using fluorescence imaging DOI: 10.1093/jac/dks161
  • Treatments no better than placebos.
  • Noninvasive biophotonic imaging for studies of infectious disease DOI: 10.1111/j.1574-6976.2010.00252.x
  • Citrobacter rodentium is an unstable pathogen showing evidence of significant genomic flux DOI: 10.1371/journal.ppat.1002018
  • Noninvasive biophotonic imaging for studies of infectious disease DOI: 10.1111/j.1574-6976.2010.00252.x
  • Sensitive detection of gene expression in mycobacteria under replicating and non-replicating conditions using optimized far-red reporters. DOI: 10.1371/journal.pone.0009823
  • Sensitive detection of gene expression in mycobacteria under replicating and non-replicating conditions using optimized far-red reporters.
  • Optimisation of bioluminescent reporters for use with mycobacteria. DOI: 10.1371/journal.pone.0010777
  • Optimisation of bioluminescent reporters for use with mycobacteria DOI: 10.1371/journal.pone.0010777
  • Bioluminescent Monitoring of In Vivo Colonization and Clearance Dynamics by Light-Emitting Bacteria DOI: 10.1007/978-1-60327-321-3_12
  • Bioluminescent monitoring of in vivo colonization and clearance dynamics by light-emitting bacteria. DOI: 10.1007/978-1-60327-321-3_12
  • Impact of immunization against SpyCEP during invasive disease with two streptococcal species: Streptococcus pyogenes and Streptococcus equi DOI: 10.1016/j.vaccine.2009.06.042
  • Bioluminescent monitoring of in vivo colonization and clearance dynamics by light-emitting bacteria DOI: 10.1007/978-1-60327-321-3-12
  • The effect of ultraviolet B-induced vitamin D levels on host resistance to Mycobacterium tuberculosis: a pilot study in immigrant Asian adults living in the United Kingdom DOI: 10.1111/j.1600-0781.2008.00339.x
  • In vivo imaging of gene transfer to the respiratory tract DOI: 10.1016/j.biomaterials.2007.11.017
  • The p50 subunit of NF-κB is critical for in vivo clearance of the noninvasive enteric pathogen Citrobacter rodentium DOI: 10.1128/IAI.00736-08
  • The effect of ultraviolet B-induced vitamin D levels on host resistance to Mycobacterium tuberculosis: A pilot study in immigrant Asian adults living in the United Kingdom DOI: 10.1111/j.1600-0781.2008.00339.x
  • Role of NleH, a type III secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut DOI: 10.1128/IAI.00742-08
  • In vivo imaging of gene transfer to the respiratory tract DOI: 10.1016/j.biomaterials.2007.11.017
  • Use of biophotonic imaging as a training aid for administration of substances in laboratory rodents DOI: 10.1258/002367707781282785
  • Use of biophotonic imaging as a training aid for administration of substances in laboratory rodents DOI: 10.1258/002367707781282785
  • Cell attachment properties and infectivity of host-adapted and environmentally adapted Citrobacter rodentium DOI: 10.1016/j.micinf.2007.06.006
  • Modelling infectious disease — time to think outside the box? DOI: 10.1038/nrmicro1386
  • Modelling infectious disease - Time to think outside the box? DOI: 10.1038/nrmicro1386
  • In vivo bioluminescence imaging of the murine pathogen Citrobacter rodentium DOI: 10.1128/IAI.00848-06
  • Essential role of the type III secretion system effector NleB in colonization of mice by Citrobacter rodentium DOI: 10.1128/IAI.74.4.2328-2337.2006
  • Emergence of a 'hyperinfectious' bacterial state after passage of Citrobacter rodentium through the host gastrointestinal tract DOI: 10.1111/j.1462-5822.2005.00544.x
  • Calibration and deployment of custom-designed bioreporters for protecting biological remediation consortia from toxic shock DOI: 10.1111/j.1462-2920.2004.00703.x
  • Tetracycline-inducible gene regulation in mycobacteria. DOI: 10.1093/nar/gni023
  • Tetracycline-inducible gene regulation in mycobacteria.
  • EspJ is a prophage-carried type III effector protein of attaching and effacing pathogens that modulates infection dynamics DOI: 10.1128/IAI.73.2.679-686.2005
  • Erratum: Organ-specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium (Cellular Microbiology (2004)) DOI: 10.1111/j.1462-5822.2004.00479.x
  • Emergence of a 'hyperinfectious' bacterial state after passage of Citrobacter rodentium through the host gastrointestinal tract DOI: 10.1111/j.1462-5822.2005.00544.x
  • Citrobacter rodentium of mice and man DOI: 10.1111/j.1462-5822.2005.00625.x
  • Calibration and deployment of custom-designed bioreporters for protecting biological remediation consortia from toxic shock DOI: 10.1111/j.1462-2920.2004.00703.x
  • Alternative luciferase for monitoring bacterial cells under adverse conditions DOI: 10.1128/AEM.71.7.3427-3432.2005
  • Organ specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium DOI: 10.1111/j.1462-5822.2004.00414.x
  • Organ specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium DOI: 10.1111/j.1462-5822.2004.00414.x
  • Development of bespoke bioluminescent reporters with the potential for in situ deployment within a phenolic-remediating wastewater treatment system DOI: 10.1016/S0167-7012(03)00203-3
  • Whole cell immobilised biosensors for toxicity assessment of a wastewater treatment plant treating phenolics-containing waste DOI: 10.1016/S0003-2670(03)00358-1
  • Whole cell immobilised biosensors for toxicity assessment of a wastewater treatment plant treating phenolics-containing waste DOI: 10.1016/S0003-2670(03)00358-1
  • Development of bespoke bioluminescent reporters with the potential for in situ deployment within a phenolic-remediating wastewater treatment system DOI: 10.1016/S0167-7012(03)00203-3
  • Ecological and physiological analyses of Pseudomonad species within a phenol remediation system DOI: 10.1016/S0167-7012(00)00231-1
  • Ecological and physiological analyses of Pseudomonad species within a phenol remediation system DOI: 10.1016/S0167-7012(00)00231-1
  • BIOMATE: DEVELOPMENT OF CUSTOM-DESIGNED BIOLUMINESCENT SENSORS FOR TOXICITY TESTING DOI: 10.1142/9789812811158_0077

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Co-workers & collaborators

Hannah Read

Hannah Read

Siouxsie Wiles's public data