Nicholas Knowlton

Publications

• Methods for inflammatory disease management
• Methods, System, And Medium For Associating Rheumatoid Arthritis Subjects With Cardiovascular Disease
• Apolipoprotein B--containing lipoprotein subclasses as risk factors for cardiovascular disease in patients with rheumatoid arthritis
• Methods for diagnosis and prognosis of inflammatory bowel disease using cytokine profiles
• Biomarkers and methods for measuring and monitoring inflammatory disease activity
• Cytokine profiles as methods for diagnosis and prognosis of irritable bowel syndrome
• Gene Expression-Based Differential Diagnostic Model for Rheumatoid Arthritis
• In silico models of leukocyte gene expression data in children with polyarticular JIA show hub-and-node structures typical of scale-free networks: Implications for pathogenesis and treatment
• Estrogen receptor signaling promotes langerin+ dendritic cell differentiation by increasing expression of the transcription factor IRF4 (87.1)
• Methods, System, and Medium for Associating Rheumatoid Arthritis Subjects with Cardiovascular Disease
• Gene expression profiling in juvenile dermatomyositis suggests complex interactions between 2 innate and adaptive immunity
• Leveraging Cancer Genomics to Answer Clinically Motivated Questions: A Statistical Perspective
• Development of a multivariate disease activity test in rheumatoid arthritis
• Mlcroarray analysis In TNBS colitis
• A Predictor of Early Disease Recurrence in Patients With Breast Cancer Using a Cell-free RNA and Protein Liquid Biopsy
• Validation of the power model of ovarian non-growing follicle depletion associated with aging
• Methods For Inflammatory Disease Management
• The NETwork! Registry Suggests Increasing Incidence in a National Study of Neuroendocrine Cancer in New Zealand (NZ)
• Novel Biomarkers for the Prediction of Subclinical Coronary Artery Atherosclerosis in Patients with Rheumatoid Arthritis
• Three distinct genomic landscapes define clinical outcome of pancreatic neuroendocrine tumours (pNETs)
• Brief FASD prevention intervention: physicians’ skills demonstrated in a clinical trial in Russia
• lymphatic, and inflammatory cell responses of the bladder to intravesical BCG treatment
• Neutrophil regulation of adaptive immunity: an in vitro model identifies hubs and nodes with similarities to those seen in polyarticular JIA
• Defining remission in polyarticular JIA: A systems biology approach
• N-Methyl-D-Aspartate Receptor Hypofunction in Meg-01 Cells Reveals a Role for Intracellular Calcium Homeostasis in Balancing Megakaryocytic-Erythroid Differentiation
• Breast cancer patient prognosis is determined by the interplay between TP53 mutation and alternative transcript expression: Insights from TP53 long amplicon digital PCR assays
• Apolipoprotein B-containing lipoprotein subclasses as risk factors for cardiovascular disease in patients with rheumatoid arthritis
• Brief FASD prevention intervention: Physicians' skills demonstrated in a clinical trial in Russia
• Accessing a new dimension in TP53 biology: Multiplex long amplicon digital pcr to specifically detect and quantitate individual TP53 transcripts
• Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma
• Gene expression profiling of breast tumours from New Zealand patients
• A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause
• Apolipoprotein-defined lipoprotein abnormalities in rheumatoid arthritis patients and their potential impact on cardiovascular disease
• Gene expression profiling in neutrophils from children with polyarticular juvenile idiopathic arthritis
• Oxidative stress and inflammation in renal patients and healthy subjects
• Erroneous augmentation of multiplex assay measurements in patients with rheumatoid arthritis due to heterophilic binding by serum rheumatoid factor
• A steroid metabolizing gene variant in a polyfactorial model improves risk prediction in a high incidence breast cancer population
• Gene expression in systemic lupus erythematosus: bone marrow analysis differentiates active from inactive disease and reveals apoptosis and granulopoiesis signatures
• Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients
• Ablation of Stat3 by siRNA alters gene expression profiles in JEG-3 cells: a systems biology approach
• Validation of the power model of ovarian nongrowing follicle depletion associated with aging in women
• Tumor mutational burden is a determinant of immune-mediated survival in breast cancer
• Disease-associated pathophysiologic structures in pediatric rheumatic diseases show characteristics of scale-free networks seen in physiologic systems: implications for pathogenesis and treatment
• Correlation of ovarian reserve tests with histologically determined primordial follicle number
• Idiopathic inflammatory myopathies, signified by distinctive peripheral cytokines, chemokines and the TNF family members B-cell activating factor and a proliferation inducing ligand
• Development of a multi-biomarker disease activity test for rheumatoid arthritis
• Recurrent loss of heterozygosity correlates with clinical outcome in pancreatic neuroendocrine cancer
• Estrogen receptor signaling promotes dendritic cell differentiation by increasing expression of the transcription factor IRF4
• The meaning of clinical remission in polyarticular juvenile idiopathic arthritis: gene expression profiling in peripheral blood mononuclear cells identifies distinct disease states
• Neuropilin-VEGF signaling pathway acts as a key modulator of vascular, lymphatic, and inflammatory cell responses of the bladder to intravesical BCG treatment
• Microarray Data Analysis Toolbox (MDAT): for normalization, adjustment and analysis of gene expression data
• Hypervariable genes—experimental error or hidden dynamics
• Comparative gene expression in the bone marrow vs peripheral blood in systemic lupus erythematosus (SLE): Bone marrow better separates active from inactive patients, and evidence for apoptosis and granulopoiesis signature
• Biomarker analysis in native American Indian RA patients and their first degree relatives.
• Identification of mouse retinal genes differentially regulated by dim and bright cyclic light rearing
• The NETwork! Registry analysis supports the WHO 2017 classification in the first NET specific survival analysis for a complete population
• Serum levels of anti-müllerian hormone and the ovarian antral follicle count are correlated with ovarian non-growing follicle number
• P-684: The decline in ovarian non-growing follicle number from birth to menopause: A new model of reproductive aging
• STEPWISE DEVELOPMENT OF A MULTI-PROTEIN BIOMARKER INDEX OF RA DISEASE ACTIVITY
• P-0112: Microarray analysis in TNBS colitis: invivo effect of combination therapy with Nacetylcysteine and mesalamine on colonic tissue gene expression
• STAT3 IS A TRANSCRIPTIONAL REPRESSOR IN TROPHOBLAST-LIKE JEG3 CELLS
• Robust Estimation of Inter-chip Variability to Improve Microarray Sample Size Calculations
• Disease activity and therapeutic response assessment in RA using multiplex cytokine profiling.
• Polymorphisms of EPCR gene, anti-EPCR autoantibodies, sEPCR and cytokine levels in patients with SLE/APS.
• A novel approach to identify prognostic biomarkers in serum from patients with chronic HCV infections
• 152 DIFFERENTIAL GENE EXPRESSION IN THE BONE MARROW AND PERIPHERAL BLOOD OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE): BONE MARROW BETTER SEPARATES ACTIVE FROM INACTIVE LUPUS PATIENTS
• Automated multiplexed cytokine bead assays
• Hypervariable genes--experimental error or hidden dynamics.
• A genome-scale assessment of peripheral blood B-cell molecular homeostasis in patients with rheumatoid arthritis
• Statistical monitoring of weak spots for improvement of normalization and ratio estimates in microarrays
• Connective molecular pathways of experimental bladder inflammation
• Discriminators of mouse bladder response to intravesical Bacillus Calmette-Guerin (BCG)
• Template-driven gene selection procedure
• Analysis of the interaction of extracellular matrix and phenotype of bladder cancer cells
• Multiplex serum cytokine monitoring as a prognostic tool in rheumatoid arthritis
• Circulating cytokines in Norwegian patients with psoriatic arthritis determined by a multiplex cytokine array system
• Mobile classification in microarray experiments
• Distinct profiles of Sjögren's syndrome patients with ectopic salivary gland germinal centers revealed by serum cytokines and BAFF
• Breast Cancer Patient Prognosis Is Determined by the Interplay between TP53 Mutation and Alternative Transcript Expression: Insights from TP53 Long Amplicon Digital PCR Assays
• Accessing a New Dimension in TP53 Biology: Multiplex Long Amplicon Digital PCR to Specifically Detect and Quantitate Individual TP53 Transcripts
• Analysis of HER2-Low Breast Cancer in Aotearoa New Zealand: A Nationwide Retrospective Cohort Study