Matthias Wielscher

Publications

• New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
• Epigenome-wide meta-analysis of DNA methylation and childhood asthma.
• Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.
• Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age.
• Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study.
• Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
• Association of adult lung function with accelerated biological aging.
• Determinants of accelerated metabolomic and epigenetic aging in a UK cohort.
• Strategies for validation and testing of DNA methylation biomarkers.
• DNA methylation testing and marker validation using PCR: diagnostic applications.
• Epigenome-wide association study of lung function level and its change.
• Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies.
• Exploring the role of genetic confounding in the association between maternal and offspring body mass index: evidence from three birth cohorts.
• DNA methylation links prenatal smoking exposure to later life health outcomes in offspring.
• Association of Methylation Signals With Incident Coronary Heart Disease in an Epigenome-Wide Assessment of Circulating Tumor Necrosis Factor α.
• Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration.
• Age at menarche and lung function: a Mendelian randomization study.
• Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults.
• Genetic variation in cervical preinvasive and invasive disease: a genome-wide association study.
• Genetic correlation and causal relationships between cardio-metabolic traits and lung function impairment.
• Single-Cell RNA Sequencing Reveals Tissue Compartment-Specific Plasticity of Mycosis Fungoides Tumor Cells.
• Middle age enhances expression of innate immunity genes in a female mouse model of pulmonary fibrosis.
• Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes.
• SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts.
• Age influence on hypersensitivity pneumonitis induced in mice by exposure to Pantoea agglomerans.
• Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study.
• Increased antioxidant defense mechanism in human adventitia-derived progenitor cells is associated with therapeutic benefit in ischemia.
• Methyl-binding domain protein-based DNA isolation from human blood serum combines DNA analyses and serum-autoantibody testing.
• The stem cell signature of CHH/CHG methylation is not present in 271 cancer associated 5'UTR gene regions.
• methylSCOPA and META-methylSCOPA: software for the analysis and aggregation of epigenome-wide association studies of multiple correlated phenotypes
• Early life origins of lung ageing: A study of lung function decline the ECRHS and NFBC1966 cohorts
• Increased Obesity Is Causal for Increased Inflammation—A Mendelian Randomisation Study
• Single-cell transcriptomics defines keratinocyte differentiation in avian scutate scales.
• Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.
• Meta-analyses identify DNA methylation associated with kidney function and damage.
• Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function.
• Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4.
• The power of genetic diversity in genome-wide association studies of lipids.
• 100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care - Preliminary Report.
• DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases
• A distinct CD115-erythro-myeloid precursor present at the maternal-embryonic interface and in the bone marrow of adult mice
• The Phageome in Normal and Inflamed Human Skin
• Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
• Impact of the COVID-19 pandemic on the epidemiology of severe burns
• Discovery of a previously unreported deletion in the CDKN2A gene in a case of familial melanoma in Austria
• A saturated map of common genetic variants associated with human height
• A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
• Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
• The transcriptional profile of keloidal Schwann cells
• The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study
• Identification of Genetic Risk Factors for Keratinocyte Cancer in Immunosuppressed Solid Organ Transplant Recipients: A Case-Control Study
• The phageome in normal and inflamed human skin