Manuel Portero-Otin

Publications

• Deregulation of purine metabolism in Alzheimer's disease
• Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy
• Targeted activation of CREB in reactive astrocytes is neuroprotective in focal acute cortical injury
• Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis
• Specific metabolomics adaptations define a differential regional vulnerability in the adult human cerebral cortex
• Metabolomics in ischaemic stroke, new diagnostic and prognostic biomarkers,La metabolómica en el ictus isquémico, nuevos biomarcadores diagnósticos y pronósticos
• Gut microbiota interacts with brain microstructure and function
• The Antioxidant Effect of LMN Diet, Rich in Polyphenols and Polyunsaturated Fatty Acids, in Alzheimer's Disease
• Erratum: Obesity changes the human gut mycobiome (Scientific Reports (2016) 5 (14600) DOI: 10.1038/srep14600)
• Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy
• Nutridynamics: Mechanism(s) of action of bioactive compounds and their effects
• Neuroinflammatory signals in alzheimer disease and APP/PS1 transgenic mice: Correlations with plaques, tangles, and oligomeric species
• Metabolomics of human brain aging and age-related neurodegenerative diseases
• Metabolomics uncovers the role of adipose tissue PDXK in adipogenesis and systemic insulin sensitivity
• Human Aging Is a Metabolome-related Matter of Gender
• Lipidomics of Human Brain Aging and Alzheimer's Disease Pathology
• Brain iron overload, insulin resistance, and cognitive performance in obese subjects: A preliminary MRI case-control study
• Oral intake of genetically engineered high-carotenoid corn ameliorates hepatomegaly and hepatic steatosis in PTEN haploinsufficient mice
• Obesity changes the human gut mycobiome
• Metabolomics Predicts Neuroimaging Characteristics of Transient Ischemic Attack Patients
• Plasma antioxidant capacity in critical polytraumatized patients?: Methods, severity, and anatomic location
• Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux
• Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer
• Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice
• Membrane lipid unsaturation as physiological adaptation to animal longevity
• Metabolomics predicts stroke recurrence after transient ischemic attack
• Dietary Lipid Unsaturation Influences Survival and Oxidative Modifications of an Amyotrophic Lateral Sclerosis Model in a Gender-Specific Manner
• The distribution of carotenoids in hens fed on biofortified maize is influenced by feed composition, absorption, resource allocation and storage
• Dietary advanced glycation end products and their role in health and disease
• Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity
• Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism
• Neuroinflammatory gene regulation, mitochondrial function, oxidative stress, and brain lipid modifications with disease progression in tau P301S transgenic mice as a model of frontotemporal lobar degeneration-tau
• Plasma lipidomics discloses metabolic syndrome with a specific HDL phenotype
• Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity
• Resveratrol Improves Motoneuron Function and Extends Survival in SOD1G93A ALS Mice
• Selected cryptic exons accumulate in hippocampal cell nuclei in Alzheimer's disease with and without associated TDP-43 proteinopathy.
• Non-Enzymatic Modification of Aminophospholipids by Carbonyl-Amine Reactions
• Human omental and subcutaneous adipose tissue exhibit specific lipidomic signatures.
• Atherosclerosis prevention by nutritional factors: A meta-analysis in small animal models
• Dietary intake of green tea polyphenols regulates insulin sensitivity with an increase in AMP-activated protein kinase content and changes in mitochondrial respiratory complexes
• Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: effects of caloric and methionine restriction
• Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy
• Lipidomic and metabolomic analyses reveal potential plasma biomarkers of early atheromatous plaque formation in hamsters
• Membrane unsaturation contributes to stress resistance and longevity of wild-type and long-lived mutant strains of Drosophila melanogaster
• Metabolomic Profile of Endometriod Adenocarcinoma of the Endometrium
• Metabolomic profiling of patients with recurrent transient ischemic attack
• Metabolomics in ischaemic stroke, new diagnostic and prognostic biomarkers
• Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy
• Plasma long-chain free fatty acids predict mammalian longevity
• Calpain activation and CaMKIV reduction in spinal cords from hSOD1G93A mouse model
• Type-Dependent Oxidative Damage in Frontotemporal Lobar Degeneration
• Beneficial effects of hematopoietic stem cell transplantation in a mouse model of X-linked Adrenoleukodystrophy
• Amyloid Generation and Dysfunctional Immunoproteasome Activation with Disease Progression in Animal Model of Familial Alzheimer's Disease
• Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress
• Cellular dysfunction in diabetes as maladaptive response to mitochondrial oxidative stress.
• Dietary supplementation of krill oil attenuates inflammation and oxidative stress in experimental ulcerative colitis in rats
• Fish oil and 3-thia fatty acid have additive effects on lipid metabolism but antagonistic effects on oxidative damage when fed to rats for 50 weeks
• Lipid peroxidizability as a potential trade-off of increased tissular docosahexaenoic acid concentrations in neurodegenerative processes
• Lipidome analysis in multiple sclerosis reveals protein lipoxidative damage as a potential pathogenic mechanism
• Lipidome analysis in multiple sclerosis reveals protein lipoxidative damage as a potential pathogenic mechanism
• Hematopoietic stem cell transplantation improves the phenotype of mouse models of X-linked Adrenoleukodystrophy
• [A study of selective neuronal vulnerability in the human central nervous system].
• Reduction in mitochondrial membrane peroxidizability index and protein lipoxidation levels in the rat heart after beta-adrenergic receptor signaling interruption with the beta-blocker atenolol
• Skeletal muscle mitochondrial uncoupling induces a metabolic rescue cycle involving FGF21 as a myokine
• Plurality of opinion, scientific discourse and pseudoscience: an in depth analysis of the Seralini et al. study claiming that Roundup (TM) Ready corn or the herbicide Roundup (TM) cause cancer in rats
• Beneficial effects of hematopoietic stem cell transplantation in a mouse model of X-linked Adrenoleukodystrophy
• Cellular dysfunction in diabetes as maladaptive response to mitochondrial oxidative stress.
• Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system
• Specific Lipidome Signatures in Central Nervous System from Methionine-Restricted Mice
• Vitamin D receptor BsmI polymorphism modulates soy intake and 25-hydroxyvitamin D supplementation benefits in cardiovascular disease risk factors profile
• [Metabolomics in ischaemic stroke, new diagnostic and prognostic biomarkers].
• Hematopoietic stem cell transplantation improves the phenotype of mouse models of X-linked Adrenoleukodystrophy
• Lipid peroxidizability as a potential trade-off of increased tissular docosahexaenoic acid concentrations in neurodegenerative processes
• Resveratrol Improves Motoneuron Function and Extends Survival in SOD1G93A ALS Mice
• Redox proteomic profiling of neuroketal-adducted proteins in human brain: Regional vulnerability at middle age increases in the elderly
• Randomised intervention study to assess the prevalence of subclinical vascular disease and hidden kidney disease and its impact on morbidity and mortality: The ILERVAS project,Estudio de intervención aleatorizado para evaluar la prevalencia de enfermedad ateromatosa y renal ocultas y su impacto en la morbimortalidad: Proyecto ILERVAS
• A salmon peptide diet alleviates experimental colitis as compared with fish oil
• Randomised intervention study to assess the prevalence of subclinical vascular disease and hidden kidney disease and its impact on morbidity and mortality: The ILERVAS project
• Novel role of TAR-DNA-binding protein-43 in mitochondria and the regulation of oxidative phosphorylation
• Oxidative damage compromises energy metabolism in the axonal degeneration mouse model of X-adrenoleukodystrophy
• Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: Implications in ALS
• Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy
• Pathological aspects of lipid peroxidation
• A fish oil-rich diet reduces vascular oxidative stress in apoE/ mice
• Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q 10
• Biomarkers of aging in Drosophila
• Coenzyme Q addition to an n-6 PUFA-rich diet resembles benefits on age-related mitochondrial DNA deletion and oxidative stress of a MUFA-rich diet in rat heart
• Depletion of oxidative and endoplasmic reticulum stress regulators in Pick disease
• Double-edged sword behaviour of gallic acid and its interaction with peroxidases in human microvascular endothelial cell culture (HMEC-1). Antioxidant and pro-oxidant effects
• Double-edged sword behaviour of gallic acid and its interaction with peroxidases in human microvascular endothelial cell culture (HMEC-1). Antioxidant and pro-oxidant effects
• Double-edged sword behaviour of gallic acid and its interaction with peroxidases in human microvascular endothelial cell culture (HMEC-1). Antioxidant and pro-oxidant effects.
• Effects of Increased Iron Intake During the Neonatal Period on the Brain of Adult A beta PP/PS1 Transgenic Mice
• Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction
• Forty percent methionine restriction lowers DNAmethylation, complex i ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart
• Glycation of mitochondrial proteins, oxidative stress and aging,Glicación de proteínas mitocondriales, estrés oxidativo y envejecimiento
• Mitochondrial ATP-synthase in the entorhinal cortex is a target of oxidative stress at stages I/II of alzheimer's disease pathology
• Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice
• Mitochondrial dysfunction and oxidative and endoplasmic reticulum stress in argyrophilic grain disease
• Multicompartmental LC-Q-TOF-Based Metabonomics as an Exploratory Tool to Identify Novel Pathways Affected by Polyphenol-Rich Diets in Mice
• Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: A paradigm for multifactorial neurodegenerative diseases?
• Plant-Derived Phenolics Inhibit the Accrual of Structurally Characterised Protein and Lipid Oxidative Modifications
• Plant-derived phenolics inhibit the accrual of structurally characterised protein and lipid oxidative modifications.
• Tetradecylthioacetic acid attenuates inflammation and has antioxidative potential during experimental colitis in rats
• Novel role of TAR-DNA-binding protein-43 in mitochondria and the regulation of oxidative phosphorylation
• Plant-derived phenolics inhibit the accrual of structurally characterised protein and lipid oxidative modifications.
• Endogenous Toxins Associated with Life Expectancy and Aging
• T-type calcium channel blockers inhibit autophagy and promote apoptosis of malignant melanoma cells
• Modification of brain lipids but not phenotype in α-synucleinopathy transgenic mice by long-term dietary n-3 fatty acids
• Protein Targets of Oxidative Damage in Human Neurodegenerative Diseases with Abnormal Protein Aggregates
• Protein and lipid oxidative damage and complex I content are lower in the brain of budgerigar and canaries than in mice. Relation to aging rate
• Evidence of oxidative stress in the neocortex in incidental Lewy body disease
• Increased oxidation, glycoxidation, and lipoxidation of brain proteins in prion disease
• Implication of oxidative and endoplasmic reticulum stress in Pick's disease
• Stimulation of Suicidal Erythrocyte Death by Methylglyoxal
• Effects of fasting on oxidative stress in rat liver mitochondria
• Methionine restriction decreases endogenous oxidative molecular damage and increases mitochondrial biogenesis and uncoupling protein 4 in rat brain
• Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy
• Stanozolol treatment decreases the mitochondrial ROS generation and oxidative stress induced by acute exercise in rat skeletal muscle.
• The beta-Blocker Atenolol Lowers the Longevity-Related Degree of Fatty Acid Unsaturation, Decreases Protein Oxidative Damage, and Increases Extracellular Signal-Regulated Kinase Signaling in the Heart of C57BL/6 Mice
• ANTIOXIDANTS AS A THERAPEUTIC HOPE FOR X-LINKED ADRENOLEUKODYSTROPHY
• Cell Death and Learning Impairment in Mice Caused by in Vitro Modified Pro-NGF Can Be Related to Its Increased Oxidative Modifications in Alzheimer Disease
• Dietary antioxidants interfere with Amplex Red-coupled-fluorescence assays
• Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liver
• Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liver
• Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver
• Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver
• Effect of every other day feeding on mitochondrial free radical production and oxidative stress in mouse liver
• Effect of graded corticosterone treatment on aging-related markers of oxidative stress in rat liver mitochondria
• Effect of insulin and growth hormone on rat heart and liver oxidative stress in control and caloric restricted animals
• Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart
• Erratum: Type-dependent oxidative damage in frontotemporal lobar degeneration: Cortical astrocytes are targets of oxidative damage (Journal of Neuropathology and Experimental Neurology 67:12 (1122-1136))
• Evidence of oxidative stress in the neocortex in incidental Lewy body disease
• Evidence of oxidative stress in the neocortex in incidental Lewy body disease
• Flight activity, mortality rates, and lipoxidative damage in Drosophila
• Flight activity, mortality rates, and lipoxidative damage in Drosophila
• Glial fibrillary acidic protein is a major target of glycoxidative and lipoxidative damage in Pick's disease
• Hyperglycemia and glycation in diabetic complications
• Inhibition of renin angiotensin system decreases renal protein oxidative damage in diabetic rats
• Methionine restriction decreases endogenous oxidative molecular damage and increases mitochondrial biogenesis and uncoupling protein 4 in rat brain
• Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins
• Methylglyoxal induces advanced glycation end product (AGEs) formation and dysfunction of PDGF receptor-β: Implications for diabetic atherosclerosis
• Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis
• Rheumatic fever: Underlying entity in acase of tonsillitis,Fiebre reumática: Entidad subyacente en un caso de amigdalitis
• Stimulation of suicidal erythrocyte death by methylglyoxal
• Survival and death of mature avian motoneurons in organotypic slice culture: Trophic requirements for survival and different types of degeneration
• Type-Dependent Oxidative Damage in Frontotemporal Lobar Degeneration: Cortical Astrocytes Are Targets of Oxidative Damage
• When cholesterol is not cholesterol: A note on the enzymatic determination of its concentration in model systems containing vegetable extracts
• When cholesterol is not cholesterol: a note on the enzymatic determination of its concentration in model systems containing vegetable extracts.
• Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy
• Type-Dependent Oxidative Damage in Frontotemporal Lobar Degeneration: Cortical Astrocytes Are Targets of Oxidative Damage
• Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liver
• Evidence of oxidative stress in the neocortex in incidental Lewy body disease
• Implication of oxidative and endoplasmic reticulum stress in Pick's disease
• Flight activity, mortality rates, and lipoxidative damage in Drosophila
• Stimulation of suicidal erythrocyte death by methylglyoxal
• Maillard reaction versus other nonenzymatic modifications in neurodegenerative processes
• Effect of experimental and cold exposure induced hyperthyroidism on H 2O2 production and susceptibility to oxidative stress of rat liver mitochondria
• Protein oxidative damage in rat liver and heart during the ageing process,Lesión oxidativa de proteínas de hígado y corazón de rata durante el proceso de envejecimiento
• Advanced glycation end products in urine: Are some sugar-derived products better than others?
• A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling
• Cold-induced hyperthyroidism produces oxidative damage in rat tissues and increases susceptibility to oxidants
• Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls
• Protein nonenzymatic modifications and proteasome activity in skeletal muscle from the short-lived rat and long-lived pigeon
• Aging increases N-epsilon-(Carboxymethyl)lysine and caloric restriction decreases N-epsilon-(Carboxyethyl)lysine and N-epsilon- (Malondialdehyde)lysine in rat heart mitochondrial proteins (vol 36, pg 47, 2002)
• Effect of ageing and caloric restriction on specific markers of protein oxidative damage and membrane peroxidizability in rat liver mitochondria
• Correlation of fatty acid unsaturation of the major liver mitochondrial phospholipid classes in mammals to their maximum life span potential
• A low degree of fatty acid unsaturation leads to lower lipid peroxidation and lipoxidation-derived protein modification in heart mitochondria of the longevous pigeon than in the short-lived rat
• A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling
• Advanced glycation end product precursors impair epidermal growth factor receptor signaling
• Advanced glycation end product precursors impair epidermal growth factor receptor signaling
• Advanced glycation end products in urine: Are some sugar-derived products better than others?
• Chemical and immunological characterization of oxidative nonenzymatic protein modifications in dialysis fluids
• Chemical and immunological characterization of oxidative nonenzymatic protein modifications in dialysis fluids
• Double bond content of phospholipids and lipid peroxidation negatively correlate with maximum longevity in the heart of mammals
• Effect of the degree of fatty acid unsaturation of rat heart mitochondria on their rates of H2O2 production and lipid and protein oxidative damage
• Erratum: Aging increases Nepsilon-(carboxymethyl)lysine and caloric restriction decreases Nepsilon-(carboxymethyl)lysine and Nepsilon-(malondialdehyde)lysine in rat heart mitochondrial proteins (Free Radical Research (2002) vol. 36 (1) (47-54))
• Influence of hyper- and hypothyroidism on lipid peroxidation, unsaturation of phospholipids, glutathione system and oxidative damage to nuclear and mitochondrial DNA in mice skeletal muscle
• Low fatty acid unsaturation: A mechanism for lowered lipoperoxidative modification of tissue proteins in mammalian species with long life spans
• Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: A homeoviscous-longevity adaptation?
• Methylglyoxal and methylglyoxal-derived advanced glycation end products of hemoglobin Type 1 diabetes with and without retinopathy
• Modification of the longevity-related degree of fatty acid unsaturation modulates oxidative damage to proteins and mitochondrial DNA in liver and brain
• Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3
• Protein methionine content and MDA-lysine adducts are inversely related to maximum life span in the heart of mammals
• Protein modification by advanced Maillard adducts can be modulated by dietary polyunsaturated fatty acids
• Protein modification by advanced Maillard adducts can be modulated by dietary polyunsaturated fatty acids
• Protein modification by advanced Maillard adducts can be modulated by dietary polyunsaturated fatty acids
• Protein oxidative stress in dialysis patients.
• Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation - Effects of Alzheimer disease and identification of lipoxidation targets
• Rapid and complete reversal of the effect of dietary restriction on protein oxidative damage in Drosophila
• Regulation of longevity by mitochondria: Role of free radical production and membrane unsaturation. A comparative approach
• Rapid and complete reversal of the effect of dietary restriction on protein oxidative damage in Drosophila
• Regulation of longevity by mitochondria: Role of free radical production and membrane unsaturation. A comparative approach
• Advanced glycation end products in urine: Are some sugar-derived products better than others?
• A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling
• Chemical and immunological characterization of oxidative nonenzymatic protein modifications in dialysis fluids
• Protein modification by advanced Maillard adducts can be modulated by dietary polyunsaturated fatty acids
• Advanced glycation end product precursors impair epidermal growth factor receptor signaling
• Aging increases N-epsilon-(Carboxymethyl)lysine and caloric restriction decreases N-epsilon-(Carboxyethyl)lysine and N-epsilon- (Malondialdehyde)lysine in rat heart mitochondrial proteins (vol 36, pg 47, 2002)
• Aging increases N-epsilon-(carboxymethyl)lysine and caloric restriction decreases N-epsilon-(carboxyethyl)lysine and N-epsilon-(malondialdehyde)lysine in rat heart mitochondrial proteins
• Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span - A homeoviscous-longevity adaptation?
• Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls
• Correlation of fatty acid unsaturation of the major liver mitochondrial phospholipid classes in mammals to their maximum life span potential
• Effect of the degree of fatty acid unsaturation of rat heart mitochondria on their rates of H2O2 production and lipid and protein oxidative damage
• Influence of hyper- and hypothyroidism on lipid peroxidation, unsaturation of phospholipids, glutathione system and oxidative damage to nuclear and mitochondrial DNA in mice skeletal muscle
• Double bond content of phospholipids and lipid peroxidation negatively correlate with maximum longevity in the heart of mammals
• Low fatty acid unsaturation: A mechanism for lowered lipoperoxidative modification of tissue proteins in mammalian species with long life spans
• Maillard-reaction derived oxoaldehydes inhibit epidermal-growth factor receptor activity in human cultured endothelial cells
• A low degree of fatty acid unsaturation leads to lower lipid peroxidation and lipoxidation-derived protein modification in heart mitochondria of the longevous pigeon than in the short-lived rat
• Effect of thyroid status on lipid composition and peroxidation in the mouse liver
• Carboxymethylated phosphatidylethanolamine in mitochondrial membranes of mammals. Evidence for intracellular lipid glycoxidation
• Chromatographic evidence for pyrraline formation during protein glycation in vitro and in vivo
• Diabetes induces an impairment in the proteolytic activity against oxidized proteins and a heterogeneous effect in nonenzymatic protein modifications in the cytosol of rat liver and kidney
• Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse
• Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals
• Pyrraline ether crosslinks as a basis for protein crosslinking by the advanced Maillard reaction in aging and diabetes
• Relationship between fatty acid unsaturation, sensitivity to lipid peroxidation, and maximum life span in the liver of mammals
• Report of a 1998 EASD-Bayer travel fellowship for Young scientists. Effect of oxidized LDL and glucose in tyrosine kinase receptors.
• Thyroid status modulates glycoxidative and lipoxidative modification of tissue proteins
• Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse
• Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse.
• Report of a 1998 EASD-Bayer Travel Fellowship for Yound Scientists - Effect of oxidized LDL and glucose in tyrosine kinase receptors
• Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals
• Relationship between fatty acid unsaturation, sensitivity to lipid peroxidation, and maximum life span in the liver of mammals
• Glycaemic control and in vivo non-oxidative Maillard reaction: urinary excretion of pyrraline in diabetes patients
• Urinary pyrraline as a biochemical marker of non-oxidative Maillard reactions in vivo
• Ageing of proteins: Urinary excretion for pyrraline (epsilon-2-(formyl-5-hydroxymethyl-pyrrol-1-yl)-L-norleucine) formed during Maillard reaction in vivo
• Pentosidine: Ageing marker for lung collagen
• AGE-RELATED FLUORESCENCE IN RAT LUNG COLLAGEN
• CHROMATOGRAPHIC EVIDENCE FOR AMADORI PRODUCT FORMATION IN RAT-LIVER AMINOPHOSPHOLIPIDS
• CHROMATOGRAPHIC EVIDENCE FOR PYRRALINE FORMATION DURING PROTEIN GLYCATION IN-VITRO AND IN-VIVO
• EVIDENCE FOR THE MAILLARD REACTION IN RAT LUNG COLLAGEN AND ITS RELATIONSHIP WITH SOLUBILITY AND AGE
• MECHANISMS OF GLYCATION IN ATHEROGENESIS
• RELATIONSHIP BETWEEN SOLUBILITY AND FLUORESCENCE DUE TO GLYCOXIDATION PRODUCTS IN RAT LUNG COLLAGEN
• Structure of advanced Maillard reaction products and their pathological role
• Glycaemic control and in vivo non-oxidative Maillard reaction: Urinary excretion of pyrraline in diabetes patients
• Urinary pyrraline as a biochemical marker of non-oxidative Maillard reactions in vivo
• Thyroid status modulates glycoxidative and lipoxidative modification of tissue proteins
• Carboxymethylated phosphatidylethanolamine in mitochondrial membranes of mammals - Evidence for intracellular lipid glycoxidation
• Effect of thyroid status on lipid composition and peroxidation in the mouse liver
• Diabetes induces an impairment in the proteolytic activity against oxidized proteins and a heterogeneous effect in nonenzymatic protein modifications in the cytosol of rat liver and kidney
• Aberrant regulation of the GSK-3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy
• Lipidomic profiling identifies signatures of metabolic risk.
• Altered Expression of miR-181a-5p and miR-23a-3p Is Associated with Obesity and TNF α -Induced Insulin Resistance
• Lipid Profile in Human Frontal Cortex Is Sustained Throughout Healthy Adult Life Span to Decay at Advanced Ages
• Acute ischemic stroke triggers a cellular senescence-associated secretory phenotype
• Cardiac fibroblasts display endurance to ischemia, high ROS control and elevated respiration regulated by the JAK2/STAT pathway
• Characterization of antioxidant properties and metabolite profile of Agave atrovirens extracts
• Tumour-microenvironmental blood flow determines a metabolomic signature identifying lysophospholipids and resolvin D as biomarkers in endometrial cancer patients
• Metabolomics reveals that fittest trail runners show a better adaptation of bioenergetic pathways
• Cryptic exon splicing function of TARDBP interacts with autophagy in nervous tissue
• Subjects with detectable Saccharomyces cerevisiae in the gut microbiota show deficits in attention and executive function
• Essential Physiological Differences Characterize Short- and Long-Lived Strains of Drosophila melanogaster
• Nuclear lipidome is altered in amyotrophic lateral sclerosis: A preliminary study
• Modulation of mitochondrial and inflammatory homeostasis through RIP140 is neuroprotective in an adrenoleukodystrophy mouse model
• Nuclear lipidome is altered in amyotrophic lateral sclerosis: A pilot study
• Metabolomic Estimation of the Diagnosis and Onset Time of Permanent and Transient Cerebral Ischemia
• New insights into human prefrontal cortex aging with a lipidomics approach
• Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study
• Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance
• Selective brain regional changes in lipid profile with human aging
• Regional vulnerability to lipoxidative damage and inflammation in normal human brain aging
• Lipidomics reveals altered biosynthetic pathways of glycerophospholipids and cell signaling as biomarkers of the polycystic ovary syndrome
• Carotenoid-enriched transgenic corn delivers bioavailable carotenoids to poultry and protects them against coccidiosis
• Prevalence of chronic obstructive pulmonary disease (COPD) not diagnosed in a population with cardiovascular risk factors,Prevalencia de enfermedad pulmonar obstructiva crónica no diagnosticada en una población con factores de riesgo cardiovascular
• Dietary interventions for patients with obesity and impaired bioenergetics
• Microbiota alterations in proline metabolism impact depression
• Ischemia preconditioning induces an adaptive response that defines a circulating metabolomic signature in ischemic stroke patients
• Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function
• Microbiota alterations in proline metabolism impact on depression through GABA and ECM homeostasis
• Activating cannabinoid receptor 2 preserves axonal health through GSK-3β/NRF2 axis in adrenoleukodystrophy
• The motor neuron disease mouse model hSOD1-G93A presents a non-canonical profile of senescence biomarkers in the spinal cord
• Lipidomic alterations in the cerebral cortex and white matter in sporadic Alzheimer’s disease
• DPP9 as a Potential Novel Mediator in Gastrointestinal Virus Infection
• A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers
• Lipidomic traits of plasma and cerebrospinal fluid in amyotrophic lateral sclerosis correlate with disease progression
• Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain
• Ether Lipid-Mediated Antioxidant Defense in Alzheimer’s Disease
• Dietary Advanced Glycation End Products: Their Role in the Insulin Resistance of Aging
• Glycogen accumulation modulates life span in a mouse model of amyotrophic lateral sclerosis
• Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial
• The gut mycobiome composition is linked to carotid atherosclerosis
• Subcutaneous advanced glycation end-products and lung function according to glucose abnormalities: The ILERVAS Project
• Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: Effects of caloric and methionine restriction
• Non-enzymatic modification of aminophospholipids by carbonyl-amine reactions
• A fish oil-rich diet reduces vascular oxidative stress in apoE(-/-) mice
• Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q 10
• Mitochondrial Dysfunction and Oxidative and Endoplasmic Reticulum Stress in Argyrophilic Grain Disease
• Dietary intake of green tea polyphenols regulates insulin sensitivity with an increase in AMP-activated protein kinase α content and changes in mitochondrial respiratory complexes
• A study of selective neuronal vulnerability in the human central nervous system,Estudio de la vulnerabilidad neuronal selectiva en el sistema nervioso central humano
• Human omental and subcutaneous adipose tissue exhibit specific lipidomic signatures
• Plurality of opinion, scientific discourse and pseudoscience: An in depth analysis of the Séralini et al. study claiming that Roundup™ Ready corn or the herbicide Roundup™ cause cancer in rats
• Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q 10
• Effect of experimental and cold exposure induced hyperthyroidism on H 2O2 production and susceptibility to oxidative stress of rat liver mitochondria
• Effect of the degree of fatty acid unsaturation of rat heart mitochondria on their rates of H2O2 production and lipid and protein oxidative damage
• Phenotypic molecular features of long-lived animal species
• Lipidomic Alterations in the Cerebral Cortex and White Matter in Sporadic Alzheimer’s Disease
• Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome
• Low adherence to the Mediterranean diet is associated with increased prevalence and number of atherosclerotic plaques in the ILERVAS cohort
• Hakuna MAM-Tata: Investigating the role of mitochondrial-associated membranes in ALS
• Cyanovirin-N binds to select SARS-CoV-2 spike oligosaccharides outside of the receptor binding domain and blocks infection by SARS-CoV-2
• Human lifespan and sex-specific patterns of resilience to disease: a retrospective population-wide cohort study
• Sphingolipid desaturase DEGS1 is essential for mitochondria-associated membrane integrity
• High-Fat Diet-Induced Obesity Increases Brain Mitochondrial Complex I and Lipoxidation-Derived Protein Damage