Kevin Crofton

Publications

• Evaluation of the ToxRTool's ability to rate the reliability of toxicological data for human health hazard assessments. PMID: 25777839
• International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes. PMID: 25618548
• Putative adverse outcome pathways relevant to neurotoxicity. PMID: 25605028
• The human toxome project. PMID: 25742299
• Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA). PMID: 25261300
• In vitro and modelling approaches to risk assessment from the U.S. Environmental Protection Agency ToxCast programme. PMID: 24684691
• Environmentally relevant mixing ratios in cumulative assessments: a study of the kinetics of pyrethroids and their ester cleavage metabolites in blood and brain; and the effect of a pyrethroid mixture on the motor activity of rats. PMID: 24631210
• Development of a thyroperoxidase inhibition assay for high-throughput screening. PMID: 24383450
• t4 workshop report: Pathways of Toxicity. PMID: 24127042
• International STakeholder NETwork (ISTNET) for creating a developmental neurotoxicity testing (DNT) roadmap for regulatory purposes. PMID: 24794006
• Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors. PMID: 23899473
• Cross-species analysis of thyroperoxidase inhibition by xenobiotics demonstrates conservation of response between pig and rat. PMID: 23959146
• Current perspectives on the use of alternative species in human health and ecological hazard assessments. PMID: 23771518
• An empirical approach to sufficient similarity: combining exposure data and mixtures toxicology data. PMID: 23398277
• Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals. PMID: 23453986
• Evaluation of iodide deficiency in the lactating rat and pup using a biologically based dose-response model. PMID: 23288054
• An animal model of marginal iodine deficiency during development: the thyroid axis and neurodevelopmental outcome. PMID: 23288053
• Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals. PMID: 23052129
• In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis. PMID: 23024176
• Environmentally relevant mixtures in cumulative assessments: an acute study of toxicokinetics and effects on motor activity in rats exposed to a mixture of pyrethroids. PMID: 22872056
• Juvenile toxicity testing protocols for chemicals. PMID: 22564981
• Optimal design for the precise estimation of an interaction threshold: the impact of exposure to a mixture of 18 polyhalogenated aromatic hydrocarbons. PMID: 22640366
• Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: a dynamic and kinetic evaluation of a putative mode-of-action. PMID: 22659317
• Developmental neurotoxicity testing: a path forward. PMID: 22925214
• Developmental neurotoxicity guideline study: issues with methodology, evaluation and regulation. PMID: 22925212
• Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation. PMID: 22892558
• Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat. PMID: 21854826
• Additivity of pyrethroid actions on sodium influx in cerebrocortical neurons in primary culture. PMID: 21665567
• Comments on: 'Perinatal toxicity of cyfluthrin in mice: developmental and behavioral effects' by Soni and colleagues. PMID: 21771863
• Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment. PMID: 21309635
• Risk assessment of combined exposure to multiple chemicals: A WHO/IPCS framework. PMID: 21466831
• Marginal iodide deficiency and thyroid function: dose-response analysis for quantitative pharmacokinetic modeling. PMID: 21315791
• Defining and modeling known adverse outcome pathways: Domoic acid and neuronal signaling as a case study. PMID: 20963854
• EN DOI: 10.14573/altex.2011.1.009
• Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals. PMID: 21311847
• Developmental triclosan exposure decreases maternal and neonatal thyroxine in rats. PMID: 20954233
• In utero and lactational exposure to bisphenol A, in contrast to ethinyl estradiol, does not alter sexually dimorphic behavior, puberty, fertility, and anatomy of female LE rats. PMID: 19864446
• Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in Young Long-Evans rats. PMID: 19910387
• Splice variant specific increase in Ca2+/calmodulin-dependent protein kinase 1-gamma mRNA expression in response to acute pyrethroid exposure. PMID: 20143453
• Introduction to the special issue on emerging high throughput and complementary model screens for neurotoxicology. PMID: 19703556
• Comparison of PC12 and cerebellar granule cell cultures for evaluating neurite outgrowth using high content analysis. PMID: 19559085
• Behavioral toxicology in the 21st century: challenges and opportunities for behavioral scientists. Summary of a symposium presented at the annual meeting of the neurobehavioral teratology society, June, 2009. PMID: 20171276
• Evidence for dose-additive effects of pyrethroids on motor activity in rats. PMID: 20019907
• Thyroid-disrupting chemicals: interpreting upstream biomarkers of adverse outcomes. PMID: 19654909
• The effects of triclosan on puberty and thyroid hormones in male Wistar rats. PMID: 18940961
• A retrospective performance assessment of the developmental neurotoxicity study in support of OECD test guideline 426. PMID: 19165382
• Predictive modeling of a mixture of thyroid hormone disrupting chemicals that affect production and clearance of thyroxine. PMID: 19815844
• In vivo acute exposure to polychlorinated biphenyls: effects on free and total thyroxine in rats. PMID: 19815845
• Meeting report: moving upstream-evaluating adverse upstream end points for improved risk assessment and decision-making. PMID: 19057713
• Conversion of Developmental Neurotoxicity (DNT) information into a structure-searchable relational database DOI: 10.1016/j.ntt.2008.03.034
• Thyroid disrupting chemicals: mechanisms and mixtures. PMID: 18217984
• Undertaking positive control studies as part of developmental neurotoxicity testing: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints. PMID: 17681747
• Transcriptional response of rat frontal cortex following acute in vivo exposure to the pyrethroid insecticides permethrin and deltamethrin. PMID: 19017407
• Identification and interpretation of developmental neurotoxicity effects: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints. PMID: 17826946
• Concentration-dependent accumulation of [3H]-deltamethrin in sodium channel Nav1.2/beta1 expressing Xenopus laevis oocytes. PMID: 17574382
• Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine. PMID: 21783810
• Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies. PMID: 17589601
• Low-dose effects of ammonium perchlorate on the hypothalamic-pituitary-thyroid axis of adult male rats pretreated with PCB126. PMID: 17379623
• The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators. PMID: 17324954
• The impact of exposure to a mixture of eighteen polyhalogenated aromatic hydrocarbons on thyroid function: Estimation of an interaction threshold DOI: 10.1198/108571107x176727
• Inhalational exposure to carbonyl sulfide produces altered brainstem auditory and somatosensory-evoked potentials in Fischer 344N rats. PMID: 17079700
• Comments on: Effect of prenatal exposure of deltamethrin on the ontogeny of xenobiotic metabolizing cytochrome P450s in the brain and liver of offsprings [Johri et al. Toxicol Appl Pharmacol. 214:279-289, 2006]. PMID: 17157340
• Influence of dosing volume on the neurotoxicity of bifenthrin. PMID: 17321720
• Bromate: concern for developmental neurotoxicity? PMID: 16516369
• Effect of PCB 126 on hepatic metabolism of thyroxine and perturbations in the hypothalamic-pituitary-thyroid axis in the rat. PMID: 16339789
• Relative potencies for acute effects of pyrethroids on motor function in rats. PMID: 16221961
• NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of amphetamine and methamphetamine. PMID: 16167346
• Thyroid-hormone-disrupting chemicals: evidence for dose-dependent additivity or synergism. PMID: 16263510
• NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of methylphenidate. PMID: 16127684
• Time and concentration dependent accumulation of [3H]-deltamethrin in Xenopus laevis oocytes. PMID: 15795096
• Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs. PMID: 15687048
• Overview: Using mode of action and life stage information to evaluate the human relevance of animal toxicity data. PMID: 16417033
• Mode of action: neurotoxicity induced by thyroid hormone disruption during development--hearing loss resulting from exposure to PHAHs. PMID: 16417043
• Mode of action: developmental thyroid hormone insufficiency--neurological abnormalities resulting from exposure to propylthiouracil. PMID: 16417044
• Behavioral test methods workshop. PMID: 15939202
• Developmental disruption of thyroid hormone: correlations with hearing dysfunction in rats. PMID: 15660619
• Accumulation of PBDE-47 in primary cultures of rat neocortical cells. PMID: 15282408
• Assessment of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture, in the EDSP male and female pubertal protocols. PMID: 14999130
• A qualitative retrospective analysis of positive control data in developmental neurotoxicity studies. PMID: 15113596
• Perinatal exposure to Aroclor 1254 impairs distortion product otoacoustic emissions (DPOAEs) in rats. PMID: 12151642
• Comparative responsiveness of hypothyroxinemia and hepatic enzyme induction in Long-Evans rats versus C57BL/6J mice exposed to TCDD-like and phenobarbital-like polychlorinated biphenyl congeners. PMID: 12151633
• Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption. PMID: 11861977
• Schedule-controlled behavior in rats exposed perinatally to the PCB mixture Aroclor 1254. PMID: 12127897
• Spatial reversal learning in Aroclor 1254-exposed rats: sex-specific deficits in associative ability and inhibitory control. PMID: 11446834
• Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats. PMID: 11294977
• Methods to identify and characterize developmental neurotoxicity for human health risk assessment. I: behavioral effects. PMID: 11250808
• Flash-, somatosensory-, and peripheral nerve-evoked potentials in rats perinatally exposed to Aroclor 1254. PMID: 11792527
• Thyroid hormone action in fetal brain development and potential for disruption by environmental chemicals. PMID: 11233763
• Spatial learning and long-term potentiation in the dentate gyrus of the hippocampus in animals developmentally exposed to Aroclor 1254. PMID: 10966516
• PCBs, thyroid hormones, and ototoxicity in rats: cross-fostering experiments demonstrate the impact of postnatal lactation exposure. PMID: 10966519
• Gestational-lactational exposure to Aroclor 1254 impairs radial-arm maze performance in male rats. PMID: 10966518
• Hearing loss following exposure during development to polychlorinated biphenyls: a cochlear site of action. PMID: 10831878
• Neurotoxic and pharmacokinetic responses to trichloroethylene as a function of exposure scenario. PMID: 10807561
• Developmental exposure to a commercial PCB mixture (Aroclor 1254) produces a persistent impairment in long-term potentiation in the rat dentate gyrus in vivo. PMID: 10629752
• Screening methods for thyroid hormone disruptors. PMID: 10210697
• Low-frequency hearing loss following perinatal exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in rats. PMID: 10386834
• Thyroxine replacement attenuates hypothyroxinemia, hearing loss, and motor deficits following developmental exposure to Aroclor 1254 in rats. PMID: 9848116
• Trichloroethylene ototoxicity: evidence for a cochlear origin. PMID: 9538045
• The ototoxicity of trichloroethylene: extrapolation and relevance of high-concentration, short-duration animal exposure data. PMID: 9268609
• Effect of methimazole, an FMO substrate and competitive inhibitor, on the neurotoxicity of 3,3'-iminodipropionitrile in male rats. PMID: 9242586
• Developmental exposure to Aroclor 1254 produces low-frequency alterations in adult rat brainstem auditory evoked responses. PMID: 8812251
• The impact of dose rate on the neurotoxicity of acrylamide: the interaction of administered dose, target tissue concentrations, tissue damage, and functional effects. PMID: 8685900
• Re: The use of uncertainty factors in estimating health risks. PMID: 8812253
• Setting exposure standards: a decision process. PMID: 9182048
• A structure-activity relationship for the neurotoxicity of triazole fungicides. PMID: 8600615
• Characterization of olfactory deficits in the rat following administration of 2,6-dichlorobenzonitrile (dichlobenil), 3,3'-iminodipropionitrile, or methimazole. PMID: 8838641
• Characterization of the effects of N-hydroxy-IDPN on the auditory, vestibular, and olfactory systems in rats. PMID: 8725642
• Effects of developmental hypothyroidism on auditory and motor function in the rat. PMID: 7482541
• Developmental exposure to polychlorinated biphenyls (Aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats. PMID: 7482542
• Assessment of offspring development and behavior following gestational exposure to inhaled methanol in the rat. PMID: 8566474
• Vehicle and route dependent effects of a pyrethroid insecticide, deltamethrin, on motor function in the rat. PMID: 7565495
• Use of Biological Markers in the Quantitative Assessment of Neurotoxic Risk DOI: 10.1016/b978-012168055-8/50063-7
• Implications of the use of neonatal birth weight, growth, viability, and survival data for predicting developmental neurotoxicity: a survey of the literature. PMID: 7542737
• Effects of 3,3'-iminodipropionitrile on the peripheral structures of the rat visual system. PMID: 8584277
• Defining neurotoxicity in a decision-making context. PMID: 7566695
• Alterations in flash evoked potentials (FEPs) in rats produced by 3,3'-iminodipropionitrile (IDPN). PMID: 8747746
• The ototoxicity of 3,3'-iminodipropionitrile: functional and morphological evidence of cochlear damage. PMID: 7896571
• Solvent-induced ototoxicity in rats: an atypical selective mid-frequency hearing deficit. PMID: 7852200
• Developmental neurotoxicity: evaluation of testing procedures with methylazoxymethanol and methylmercury. PMID: 7835545
• Relationships between biomarkers of exposure and neurological effects in a group of workers exposed to acrylamide. PMID: 8209389
• Age-dependent differences in the susceptibility of rats to deltamethrin. PMID: 8184428
• Effects of toluene inhalation on detection of auditory signals in rats. PMID: 8052189
• Effects of 3,3'-iminodipropionitrile on acquisition and performance of spatial tasks in rats. PMID: 7862057
• Developmental Neurotoxicity: Evaluation of Testing Procedures with Methylazoxymethanol and Methylmercury DOI: 10.1093/toxsci/23.3.447
• The sensitivity to 3,3′-iminodipropionitrile differs for high-and midfrequency hearing loss in the developing rat DOI: 10.1016/0378-5955(93)90111-d
• The sensitivity to 3,3'-iminodipropionitrile differs for high- and midfrequency hearing loss in the developing rat. PMID: 8226343
• Determination of acrylamide in rat serum and sciatic nerve by gas chromatography-electron-capture detection. PMID: 8263094
• Administration of 3,3'-iminodipropionitrile to the rat results in region-dependent damage to the central nervous system at levels above the brain stem. PMID: 8510024
• Characterization of disulfoton-induced behavioral and neurochemical effects following repeated exposure. PMID: 8449387
• Mid-frequency hearing loss in rats following inhalation exposure to trichloroethylene: evidence from reflex modification audiometry. PMID: 8302243
• Developmental neurotoxicity following neonatal exposure to 3,3'-iminodipropionitrile in the rat. PMID: 8510606
• Characterization of Disulfoton-Induced Behavioral and Neurochemical Effects Following Repeated Exposure DOI: 10.1093/toxsci/20.2.163
• Olfactory toxicity of beta,beta'-iminodipropionitrile in the rat. PMID: 1469644
• Behavioral development following daily episodes of mother-infant separation in the rat. PMID: 1459377
• Evaluating the effects of acrylamide and 3,3'-iminopropionitrile (IDPN), using behavioral (functional observational battery and motor activity) and neuropathological end points. PMID: 1516790
• The effects of 2,4-dithiobiuret on sensory and motor function. PMID: 1906822
• Interlaboratory comparison of motor activity experiments: implications for neurotoxicological assessments. PMID: 1779947
• Enhanced neurotoxicity of 3,3'-iminodipropionitrile following carbon tetrachloride pretreatment in the rat. PMID: 1745441
• Auditory deficits and motor dysfunction following iminodipropionitrile administration in the rat. PMID: 1779945
• Learning and memory deficits in rats following exposure to 3,3'-iminodipropionitrile. PMID: 2219122
• Trimethyltin effects on auditory function and cochlear morphology. PMID: 2392800
• Triadimefon, a triazole fungicide, induces stereotyped behavior and alters monoamine metabolism in rats. PMID: 2315916
• Triadimefon, a triazole fungicide, induces stereotyped behavior and alters monoamine metabolism in rats DOI: 10.1016/0041-008x(90)90043-t
• Reflex modification and the detection of toxicant-induced auditory dysfunction. PMID: 2247033
• An examination of the proconvulsant actions of pyrethroid insecticides using pentylenetetrazol and amygdala kindling seizure models. PMID: 2374658
• Pyrethroids and enhanced inhibition in the hippocampus of the rat. PMID: 2702491
• Prenatal or postnatal exposure to bis(tri-n-butyltin)oxide in the rat: postnatal evaluation of teratology and behavior. PMID: 2916230
• Evidence for monoaminergic involvement in triadimefon-induced hyperactivity. PMID: 2497480
• Acute effects of amitraz on the acoustic startle response and motor activity DOI: 10.1002/ps.2780270102
• The effects of type I and II pyrethroids on motor activity and the acoustic startle response in the rat. PMID: 3396790
• Hyperactivity induced by triadimefon, a triazole fungicide. PMID: 3371585
• Pyrethroid insecticides and the gamma-aminobutyric acidA receptor complex: motor activity and the acoustic startle response in the rat. PMID: 2826762
• Pyrethroid insecticides and radioligand displacement from the GABA receptor chloride ionophore complex. PMID: 3029901
• Pyrethroid effects on schedule-controlled behavior: time and dosage relationships. PMID: 3696110
• Postnatal evaluation of prenatal exposure to p-xylene in the rat. PMID: 3798481
• Effects of two pyrethroid insecticides on motor activity and the acoustic startle response in the rat. PMID: 6474463
• Effects of two pyrethroid insecticides on motor activity and the acoustic startle response in the rat DOI: 10.1016/0041-008x(84)90214-x
• Thioridazine and the neuroleptic radioreceptor assay. PMID: 6743721
• Use of environmental challenges in behavioral toxicology. PMID: 6416894
• The effects of lead on the developing central nervous system of the rat. PMID: 6308527
• Low level lead (Pb) exposure produces learning deficits in young rat pups. PMID: 7099350
• Developmental delays in exploration and locomotor activity in male rats exposed to low level lead. PMID: 7374348