Jens Luebeck

Publications

• Extrachromosomal DNA in HPV-Mediated Oropharyngeal Cancer Drives Diverse Oncogene Transcription
• AmpliconReconstructor: Integrated analysis of NGS and optical mapping resolves the complex structures of focal amplifications in cancer
• Reconstructing and characterizing focal amplifications in cancer using AmpliconArchitect
• CRISPR-Cas9 Gene Editing of Hematopoietic Stem Cells from Patients with Friedreich's Ataxia
• Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions
• Quantitative Missense Variant Effect Prediction Using Large-Scale Mutagenesis Data
• FaNDOM: Fast nested distance-based seeding of optical maps
• FaNDOM: Fast Nested Distance-Based Seeding of Optical Maps
• Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis
• Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH
• EcSeg: Semantic Segmentation of Metaphase Images Containing Extrachromosomal DNA
• ViFi: Accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer
• AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications
• Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers
• Exploring the landscape of focal amplifications in cancer using AmpliconArchitect
• The landscape of extrachromosomal circular DNA in medulloblastoma
• ecDNA hubs drive cooperative intermolecular oncogene expression
• Circular ecDNA promotes accessible chromatin and high oncogene expression
• Comprehensive analysis of clustered mutations in cancer reveals recurrent APOBEC3 mutagenesis of ecDNA