Georg Steinkellner

Publications

• Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations
• Asymmetric enzymatic hydration of hydroxystyrene derivatives
• A new esterase from Thermobifida halotolerans hydrolyses polyethylene terephthalate (PET) and polylactic acid (PLA)
• Structural insights into substrate specificity and solvent tolerance in alcohol dehydrogenase ADH-'A' from Rhodococcus ruber DSM 44541
• Fusion of binding domains to Thermobifida cellulosilytica cutinase to tune sorption characteristics and enhancing PET hydrolysis
• Crystal structure of an (R)-selective v-transaminase from aspergillus terreus
• Thermostability improvement of endoglucanase Cel7B from Hypocrea pseudokoningii
• Targeting the substrate binding site of E.coli nitrile reductase queF by modeling, substrate and enzyme engineering
• Surface engineering of a cutinase from Thermobifida cellulosilytica for improved polyester hydrolysis
• Crystallization of the novel S-adenosyl-l-methionine-dependent C-methyltransferase CouO from Streptomyces rishiriensis and preliminary diffraction data analysis
• Crystallization of a novel metal-containing cupin from Acidobacterium sp. and preliminary diffraction data analysis
• Stereopreferences of old yellow enzymes: Structure correlations and sequence patterns in enoate reductases
• Directed evolution of Alcaligenes faecalis nitrilase
• Enzymatic surface hydrolysis of PET: Effect of structural diversity on kinetic properties of cutinases from Thermobifida
• Bioreduction of α-methylcinnamaldehyde derivatives: Chemo-enzymatic asymmetric synthesis of Lilial™ and Helional™
• Improved fitness of Arabidopsis thaliana nitrilase 2
• α- and β-oxygenated aldehydes derived from Diels-Alder reactions as substrates for hydroxynitrile lyases
• Investigation of lipase-catalyzed Michael-type carbon-carbon bond formations
• VASCo: Computation and visualization of annotated protein surface contacts
• Observation of a Short, Strong Hydrogen Bond in the Active Site of Hydroxynitrile Lyase from Hevea brasiliensis Explains a Large pKa Shift of the Catalytic Base Induced by the Reaction Intermediate
• Regioselective ortho-carboxylation of phenols catalyzed by benzoic acid decarboxylases: A biocatalytic equivalent to the Kolbe-Schmitt reaction
• Polyester hydrolysis is enhanced by a truncated esterase: Less is more
• An Esterase from Anaerobic Clostridium hathewayi Can Hydrolyze Aliphatic-Aromatic Polyesters
• PpEst is a novel PBAT degrading polyesterase identified by proteomic screening of Pseudomonas pseudoalcaligenes
• Structures of almond hydroxynitrile lyase isoenzyme 5 provide a rationale for the lack of oxidoreductase activity in flavin dependent HNLs
• Regioselective enzymatic β-carboxylation of para-hydroxy-styrene derivatives catalyzed by phenolic acid decarboxylases
• Improving enzymatic polyurethane hydrolysis by tuning enzyme sorption
• The crystal structure of D-threonine aldolase from alcaligenes xylosoxidans provides insight into a metal ion assisted PLPDependent mechanism
• Structure-Based Mechanism of Oleate Hydratase from Elizabethkingia meningoseptica
• Engineering of the zinc-binding domain of an esterase from Clostridium botulinum towards increased activity on polyesters
• Exploring the Catalytic Promiscuity of Phenolic Acid Decarboxylases: Asymmetric, 1,6-Conjugate Addition of Nucleophiles Across 4-Hydroxystyrene
• Hydrolysis of synthetic polyesters by Clostridium botulinum esterases
• Evolving the Promiscuity of Elizabethkingia meningoseptica Oleate Hydratase for the Regio‐ and Stereoselective Hydration of Oleic Acid Derivatives
• Weiterentwicklung der Substrattoleranz von Elizabethkingia meningoseptica Oleathydratase zur regio‐ und stereoselektiven Hydratisierung von Ölsäurederivaten
• A fungal ascorbate oxidase with unexpected laccase activity
• Regioselective para-Carboxylation of Catechols with a Prenylated Flavin Dependent Decarboxylase
• Structural bioinformatics analysis of SARS-CoV-2 variants reveals higher hACE2 receptor binding affinity for Omicron B.1.1.529 spike RBD compared to wild type reference
• Recent changes in the mutational dynamics of the SARS-CoV-2 main protease substantiate the danger of emerging resistance to antiviral drugs
• Serine 477 plays a crucial role in the interaction of the SARS-CoV-2 spike protein with the human receptor ACE2
• Asymmetric Amination of α-Chiral Aliphatic Aldehydes via Dynamic Kinetic Resolution to Access Stereocomplementary Brivaracetam and Pregabalin Precursors
• Racemization-free and scalable amidation of l-proline in organic media using ammonia and a biocatalyst only
• The sustainable synthesis of levetiracetam by an enzymatic dynamic kinetic resolution and an: Ex-cell anodic oxidation
• Small cause, large effect: Structural characterization of cutinases from Thermobifida cellulosilytica
• Optimizing variant-specific therapeutic SARS-CoV-2 decoys using deep-learning-guided molecular dynamics simulations
• Controlling the Regioselectivity of Fatty Acid Hydroxylation (C10) at α- and β-Position by CYP152A1 (P450Bsβ) Variants
• Identification of key residues for enzymatic carboxylate reduction
• AI-assisted structural consensus-proteome prediction of human monkeypox viruses isolated within a year after the 2022 multi-country outbreak