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Davide Ortolan

Publications

  • CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization.
  • Choroid-resident macrophages maintain local vasculature and RPE integrity and spontaneously regenerate following depletion
  • Mutant prion proteins increase calcium permeability of AMPA receptors, exacerbating excitotoxicity.
  • Activation of Src family kinase ameliorates secretory trafficking in mutant prion protein cells.
  • AMPK modulation ameliorates dominant disease phenotypes of CTRP5 variant in retinal degeneration
  • Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model
  • Erratum: Mutant prion proteins increase calcium permeability of AMPA receptors, exacerbating excitotoxicity (PLoS Pathog (2020) 16:7 (e1008654) DOI: 10.1371/journal.ppat.1008654)
  • Single-cell–resolution map of human retinal pigment epithelium helps discover subpopulations with differential disease sensitivity
  • Triphasic developmentally guided protocol to generate retinal pigment epithelium from induced pluripotent stem cells
  • Efficient and Consistent Generation of Retinal Pigment Epithelium/Choroid Flatmounts from Human Eyes for Histological Analysis
  • LipidUNet-Machine Learning-Based Method of Characterization and Quantification of Lipid Deposits Using iPSC-Derived Retinal Pigment Epithelium
  • Considerations for Developing an Autologous Induced Pluripotent Stem Cell (iPSC)-Derived Retinal Pigment Epithelium (RPE) Replacement Therapy

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