Gianluca Pegoraro

Publications

• siRNA Screen Identifies Trafficking Host Factors that Modulate Alphavirus Infection
• Ageing-related chromatin defects through loss of the NURD complex
• Cell cycle staging of individual cells by fluorescence microscopy
• Quantitative detection of rare interphase chromosome breaks and translocations by high-throughput imaging
• A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages
• Identification of Gene Positioning Factors Using High-Throughput Imaging Mapping
• Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430
• Crimean-Congo hemorrhagic fever virus utilizes a clathrin- and early endosome-dependent entry pathway
• The central role of chromatin maintenance in aging.
• Regulation of adeno-associated virus DNA replication by the cellular TAF-I/set complex
• Nuclear organization and the control of HIV-1 transcription
• Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein
• Histone modifications predispose genome regions to breakage and translocation
• Shedding light on filovirus infection with high-content imaging
• Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining
• Integrating High-Content Imaging and Chemical Genetics to Probe Host Cellular Pathways Critical for Yersinia Pestis Infection
• Identification of mammalian protein quality control factors by high-throughput cellular imaging
• High-throughput imaging of mRNA at the single-cell level in human primary immune cells
• Cajal bodies are linked to genome conformation
• High-throughput Imaging as a versatile and unbiased discovery tool
• 3D Chromosome Regulatory Landscape of Human Pluripotent Cells
• CTCF is a Barrier for Totipotent-like Reprogramming
• The glucocorticoid receptor associates with the cohesin loader NIPBL to promote long-range gene regulation
• HiFENS: High-throughput FISH detection of endogenous pre-mRNA splicing isoforms
• Activation of endoplasmic reticulum stress via clustering of the inner nuclear membrane protein SUN2
• HiIDDD: a high-throughput imaging pipeline for the quantitative detection of DNA damage in primary human immune cells
• Spatiotemporal higher-order chromatin landscape of human histone gene clusters at Histone Locus Bodies during the cell cycle in breast cancer progression
• Spatiotemporal higher-order chromatin landscape of human histone gene clusters at histone locus bodies during the cell cycle in breast cancer progression
• Identification of epigenetic modulators as determinants of nuclear size and shape
• HiTIPS: High-Throughput Image Processing Software for the Study of Nuclear Architecture and Gene Expression
• Allele-level visualization of transcription and chromatin by high-throughput imaging
• Predictive Prioritization of Enhancers Associated with Pancreas Disease Risk
• Identification of Novel Modulators of the ALT Pathway Through a Native FISH-Based Optical Screen
• Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint
• Simulation and quantitative analysis of spatial centromere distribution patterns
• Optical Pooled Screening for the Discovery of Regulators of the Alternative Lengthening of Telomeres Pathway
• Mechanism for local attenuation of DNA replication at double-strand breaks