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Aravind Reddy Tarugu

Senior Research Specalist (Biological sciences)

USA

Dr. Aravind Reddy Tarugu is a lung biologist conducting in-depth research in the pathology and pathobiology of pulmonary diseases. Dr. Tarugu significantly contributed to the lung biology field, and his discoveries helped understand the molecular mechanisms in lung diseases and develop new treatment approaches. In addition to his immense achievements and contributions, Dr. Tarugu served as an academic mentor and trained and supervised other junior members, the next generation of young researchers.

Publications

  • Epigallocatechin Gallate (EGCG) – A Novel Covalent NF- κB Inhibitor: Structural and Molecular Characterization
  • Epigallocatechin gallate suppresses inflammation in human coronary artery endothelial cells by inhibiting NF-kappaB
  • Glucocorticoid Receptor alpha Mediates Roflumilast's Ability to Restore Dexamethasone Sensitivity in COPD
  • Cigarette smoke downregulates Nur77 to exacerbate inflammation in chronic obstructive pulmonary disease (COPD)
  • Epigallocatechin gallate diminishes cigarette smoke-induced oxidative stress, lipid peroxidation, and inflammation in human bronchial epithelial cells
  • The tea catechin epigallocatechin gallate inhibits NF-kappaB-mediated transcriptional activation by covalent modification
  • Bidirectional interaction of airway epithelial remodeling and inflammation in asthma
  • Molecular, chemical, and structural characterization of prostaglandin A2 as a novel agonist for Nur77
  • Key Functions and Therapeutic Prospects of Nur77 in Inflammation Related Lung Diseases
  • Identification and Molecular Characterization of Peroxisome Proliferator-Activated Receptor delta as a Novel Target for Covalent Modification by 15-Deoxy-Delta(12,14)-prostaglandin J(2)
  • Role of GPx3 in PPARgamma-induced protection against COPD-associated oxidative stress
  • Airway Epithelial Cell Peroxisome Proliferator-Activated Receptor gamma Regulates Inflammation and Mucin Expression in Allergic Airway Disease
  • PPARs: Key Regulators of Airway Inflammation and Potential Therapeutic Targets in Asthma
  • Transforming growth factor beta suppresses peroxisome proliferator-activated receptor gamma expression via both SMAD binding and novel TGF-beta inhibitory elements
  • Emerging pharmaceutical therapies for COPD
  • PPAR Agonists for the Prevention and Treatment of Lung Cancer
  • PPARgamma as a Novel Therapeutic Target in Lung Cancer
  • PPARgamma in Bacterial Infections: A Friend or Foe?
  • Nitrated Fatty Acids Reverse Cigarette Smoke-Induced Alveolar Macrophage Activation and Inhibit Protease Activity via Electrophilic S-Alkylation
  • Nitrated fatty acids reverse pulmonary fibrosis by dedifferentiating myofibroblasts and promoting collagen uptake by alveolar macrophages
  • The nitrated fatty acid 10-nitro-oleate attenuates allergic airway disease
  • Pulmonary administration of a water-soluble curcumin complex reduces severity of acute lung injury
  • The Nitrated Fatty Acid 10-Nitro-oleate Diminishes Severity of LPS-Induced Acute Lung Injury in Mice
  • Murine model of allergen induced asthma
  • Endothelial cell peroxisome proliferator-activated receptor gamma reduces endotoxemic pulmonary inflammation and injury
  • Effects of JAM-A deficiency or blocking antibodies on neutrophil migration and lung injury in a murine model of ALI
  • Role of GPx3 in PPAR$γ$-induced protection against COPD-associated oxidative stress
  • Cigarette Smoke Downregulates Nur77 to Exacerbate Airway Inflammation in Chronic Obstructive Pulmonary Disease (COPD)
  • Epigallocatechin gallate suppresses inflammation in human coronary artery endothelial cells by inhibiting NF-$κ$B
  • Glucocorticoid receptor $α$ mediates roflumilast’s ability to restore dexamethasone sensitivity in COPD
  • Airway epithelial cell peroxisome proliferator--activated receptor $γ$ regulates inflammation and mucin expression in allergic airway disease
  • Identification and Molecular Characterization of Peroxisome Proliferator-Activated Receptor $δ$ as a Novel Target for Covalent Modification by 15-Deoxy-$Δ$12, 14-prostaglandin J2
  • Peroxisome Proliferator-Activated Receptor $γ$-Mediated Regulation of Glutathione Peroxidase 3 in COPD
  • The tea catechin epigallocatechin gallate inhibits NF-$κ$B-mediated transcriptional activation by covalent modification
  • Prostaglandin A2-Mediated Activation of the Nuclear Receptor Nur77 in Lung Diseases
  • C75 FIBROSIS: CURRENT AND FUTURE APPROACHES: Transforming Growth Factor $β$ Suppresses Peroxisome Proliferator-activated Receptor $γ$ Expression Via Both Smad Binding And Novel Tgf-$β$ Inhibitory Elements
  • Essential need for rethink of COPD airway pathology: implications for new drug approaches for prevention of lung cancer as well as small airway fibrosis
  • Essential need for rethink of COPD airway pathology: implications for new drug approaches for prevention of lung cancer as well as small airway fibrosis Reply
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  • Transforming Growth Factor $β$ Suppresses Peroxisome Proliferator--Activated Receptor $γ$ Expression Via Both SMAD Binding And Novel TGF-$β$ Inhibitory Elements
  • Transforming growth factor $β$ suppresses peroxisome proliferator-activated receptor $γ$ expression via both SMAD binding and novel TGF-$β$ inhibitory elements
  • Transforming Growth Factor beta Suppresses Peroxisome Proliferator-activated Receptor. Expression Via Both Smad Binding And Novel Tgf-beta Inhibitory Elements
  • PPAR agonists for the prevention and treatment of lung cancer
  • PPARs: key regulators of airway inflammation and potential therapeutic targets in asthma
  • Key functions and therapeutic prospects of Nur77 in inflammation related lung diseases
  • D36 SEPSIS, ACUTE RESPIRATORY DISTRESS SYNDROME, AND ACUTE LUNG INJURY: Induction Of F-Box Proteins By LPS Stimulation In A Human Monocytic Cell Line: Implications In Acute Lung Injury
  • C30 LATE BREAKING ABSTRACTS IN DISEASE TREATMENT AND CLINICAL OUTCOMES: Roflumilast-Glucocorticoid Synergy In COPD
  • Cysteine S-Alkylation Of Proteases As Potential Therapeutic Mechanism For COPD
  • B110 COPD GALORE: NEW INSIGHTS INTO BRONCHITIS AND EMPHYSEMA DEVELOPMENT AND TREATMENT: Cysteine S-Alkylation Of Proteases As Potential Therapeutic Mechanism For COPD
  • PPAR𝛾 in Bacterial Infections: A Friend or Foe?
  • PPAR𝛾 as a Novel Therapeutic Target in Lung Cancer
  • Nitrated fatty acids reverse cigarette smoke-induced alveolar macrophage activation and inhibit protease activity via electrophilic S-alkylation
  • Airway Epithelial Cell Peroxisome Proliferator-Activated Receptor $γ$ (PPAR$γ$) Is A Crucial Regulator Of Allergic Airway Disease
  • Epigallocatechin gallate suppresses inflammation in human coronary artery endothelial cells by inhibiting NF-kappa B
  • C22 AIRWAY EPITHELIUM: MOLECULAR REGULATION OF INFLAMMATION: Airway Epithelial Cell Peroxisome Proliferator-Activated Receptor [gamma](ppar [gamma]) Is A Crucial Regulator Of Allergic Airway Disease
  • The nitrated fatty acid 10-nitro-oleate diminishes severity of LPS-induced acute lung injury in mice
  • Endothelial Cell Peroxisome Proliferator-Activated Receptor-Gamma Protects Against Sepsis-Induced Acute Lung Injury
  • Endothelial Cell Peroxisome Proliferator-Activated Receptor gamma Reduces Endotoxemic Pulmonary Inflammation and Injury
  • Endothelial cell peroxisome proliferator--activated receptor $γ$ reduces endotoxemic pulmonary inflammation and injury
  • The Nitrated Fatty Acid 10-Nitro-Oleate
  • Suppressing Allergic Airway Disease with Nitrated Fatty Acids
  • Nitrated Fatty Acids Inhibit Allergic Airway Disease
  • Roflumilast-glucocorticoid synergy in COPD
  • Induction Of F-Box Proteins By LPS Stimulation In A Human Monocytic Cell Line: Implications In Acute Lung Injury
  • D41 COPD: BIOMARKERS IN STABLE DISEASE AND EXACERBATIONS: Crucial Role Of Ppar [gamma] Downregulation And Activation In COPD
  • The tea catechin epigallocatechin gallate inhibits NF-kappa B-mediated transcriptional activation by covalent modification
  • Molecular, chemical, and structural characterization of prostaglandin A(2) as a novel agonist for Nur77

Aravind Reddy Tarugu's public data