Ethanol induces a biphasic change in periorbital tactile sensitivity.

Figure 1a displays an ethanol-induced biphasic change in tactile sensitivity that is specific to the rats infused with IS, also referred to as sensitized rats. Figure 1b shows no change in threshold with administration of control gavage to IS (black) and saline (grey) infused rats. Figure 1c illustrates the change in threshold relative to baseline at 0–2 hours following ethanol and 4–6 hours following ethanol. Figure 1d demonstrates the temporal variability of the biphasic response to ethanol in two individual rats that had previously been infused with IS. Note logarithmic scale.