R-markdown file and data objects for estimating TFA in TMS lung-tissue scRNA-Seq dataset

R-markdown file plus associated bib file as well as output generated (html format). To execute the Rmd file, run

rmarkdown::render("EstTFAofHemaSCIRAregulons.Rmd")
from within an R-session with rmarkdown and knitr preinstalled.

Data objects:

netHEMAinfo.Rd: contains the 328 hematopoietic SCIRA TF-regulons

doroMMnoL.Rd: contains 1179 DOROTHEA TF-regulons.

lung10Xtms.Rd: contains the lung 10X TMS scRNA-Seq dataset for DOROTHEA analysis

lung10XtmsIC.Rd: contains the lung 10X TMS scRNA-Seq dataset for the SCIRA analysis

tfaLungIC.Rd: precomputed TFA values for the 328 hematopoietic TFs in the immune cell subsets of lung-tissue

tfaLungVIP.Rd: precomputed TFA values for DOROTHEA TFs across all the main cell-types in lung-tissue (with sufficient cell-number representation across age-groups).