ppat.1009280.s002.pptx (88.9 kB)
Relative expression of the different PAIs of S. Typhimurium.
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posted on 2021-08-30, 17:33 authored by TuShun R. Powers, Amanda L. Haeberle, Alexander V. Predeus, Disa L. Hammarlöf, Jennifer A. Cundiff, Zeus Saldaña-Ahuactzi, Karsten Hokamp, Jay C. D. Hinton, Leigh A. KnodlerEach arrow represents an individual gene to scale within each PAI. The different islands are also scaled against each other. The color of each arrow represents relative gene expression–red arrows depict genes up-regulated in the cytosol (≥1.40-fold change WTM/EBSS), blue are genes up-regulated in the vacuole (≥1.40-fold change EBSS/WTM), yellow are genes with unchanged expression (0.72–1.39-fold change) and grey arrows are genes with a TPM value <10 and considered not expressed. See S1 Dataset for the entire data set. Adapted from Srikumar et al. [43].
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showed increased expressionremain largely unknownphysicochemical conditions encounteredpathogenicity island 1cell microscopic analysiscauses diarrheal diseaseparallel colonization strategiesepithelial cell lysisserovar typhimurium (<scv ), followedinduced expression signatures>- containing vacuoleidentified bacterial genesbacterial genes requiredsalmonella enterica bacterial releasesalmonella epithelial cellsvirulence genescytosolic colonizationzoonotic pathogenunusual lifestyletypically associatedtyphimurium withintyphimurium replicationtwo nichesuccessfully colonizestudy revealssoxs sita seq approachpermissive environmentoxidative stressmnth manganese deprivationmagnesium deprivationintracellular nichegastrointestinal tractfepb extracellular bacteriaepithelial cytosolenvironmental biosensorsentc begins withinbased rnaarchetypical vacuole
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