The need for effective centralized management of biomedical and behavioral research data has expanded dramatically in the past decade. Interdisciplinary, longitudinal, and multi-center research benefits from secure, flexible data management platforms. Current solutions are either insufficiently flexible or too expensive. Our team has developed an integrated data management platform used at over a dozen leading autism research centers over the last 6 years. In late 2011, we began to package this platform, originally developed as a mix of proprietary and open-source components, as an open-source project with the goal of making it freely available to all autism research centers and programs.