CXCL12-resistant Envs display amino acid changes in the epitopes for V2-apex and gp120/gp41 interface bNAbs (Related to Fig 3).

Armani-Tourret, Marie; Zhou, Zhicheng; Gasser, Romain; Staropoli, Isabelle; Cantaloube-Ferrieu, Vincent; Benureau, Yann; Garcia-Perez, Javier; Pérez-Olmeda, Mayte; Lorin, Valérie; Puissant-Lubrano, Bénédicte; Assoumou, Lambert; Delaugerre, Constance; Lelièvre, Jean-Daniel; Lévy, Yves; Mouquet, Hugo; Martin-Blondel, Guillaume; Alcami, Jose; Arenzana-Seisdedos, Fernando; Izopet, Jacques; Colin, Philippe; Lagane, Bernard

doi:10.1371/journal.ppat.1009526.s003

ppat.1009526.s003.pptx (610.02 kB)

CXCL12-resistant Envs display amino acid changes in the epitopes for V2-apex and gp120/gp41 interface bNAbs (Related to Fig 3).

presentation

posted on 2021-04-19, 17:34 authored by Marie Armani-Tourret, Zhicheng Zhou, Romain Gasser, Isabelle Staropoli, Vincent Cantaloube-Ferrieu, Yann Benureau, Javier Garcia-Perez, Mayte Pérez-Olmeda, Valérie Lorin, Bénédicte Puissant-Lubrano, Lambert Assoumou, Constance Delaugerre, Jean-Daniel Lelièvre, Yves Lévy, Hugo Mouquet, Guillaume Martin-Blondel, Jose Alcami, Fernando Arenzana-Seisdedos, Jacques Izopet, Philippe Colin, Bernard Lagane

A and B Sensitivity of SENS, RES, F8 and F9 Envs to neutralization by PG16 (A) and PGDM1400 (B). Experiments were carried out and analyzed as described in Fig 3. C RES Envs, but not SENS Envs, show amino acid substitutions in the epitope for V2-apex bNAbs. The corresponding sequence in HxB2 Env is shown as reference. The color code for the patients is the same as in Fig 3. D Different residues that comprise the epitope for PGT151 at the gp120/gp41 interface are substituted in F8 Env.

(PPTX)