ISS_Model

This is supplemental material for the article,

"Estimating Insulin Sensitivity and Beta-Cell Function from the Oral Glucose Tolerance Test: Validation of a new Insulin Sensitivity and Secretion (ISS) Model", Am. J. Physiol.

doi: https://doi.org/10.1152/ajpendo.00189.2023

PubMed: https://pubmed.ncbi.nlm.nih.gov/38054972/

Early preprint at bioRxiv, doi: https://doi.org/10.1101/2023.06.16.545377

Items:

Supplemental Table S1

Supplemental Figures S1 - S13

File S1 Supplemental Equations

File S2 Matlab Fitting Code

File S3 Python Fitting Code

File S4 Supplemental Methods

For File S2, run the Matlab script OGTT_fit.m, which calls OGTT_cost_function_universal.m and GI_ode_universal.m.

It will read in the synthetic data Synthetic_Data.xlsx and output the fits to Synthetic_Fits.xlsx. The included file Expected_Synthetic_Fits.xlsx should agree with your output.

The parameters are set to those used in the paper, but can be customized as desired.

For File S3, consult the readme.md file contained in the zip file.