ISS_Model

This is supplemental material for the article,

"Estimating Insulin Sensitivity and Beta-Cell Function from the Oral Glucose Tolerance Test: Validation of a new Insulin Sensitivity and Secretion (ISS) Model",

bioRxiv doi: https://doi.org/10.1101/2023.06.16.545377

Items:

Supplemental Table S1

Supplemental Figures S1 - S13

File S1 Supplemental Equations

File S2 Matlab Fitting Code

File S3 Python Fitting Code

File S4 Supplemental Methods

For File S2, run the Matlab script OGTT_fit.m, which calls OGTT_cost_function_universal.m and GI_ode_universal.m.

It will read in the synthetic data Synthetic_Data.xlsx and output the fits to Synthetic_Fits.xlsx.

The parameters are set to those used in the paper, but can be customized as desired.

For File S3, consult the readme.md file contained in the zip file.