Hepatitis B Virus-induced modulation of liver macrophage functions promotes hepatocyte infection

S., Faure-Dupuy; delphin, marion; aillot, ludovic; Fresquet, Judith; Parent, Romain; Matter, Matthias; Rivoire, Michel; Bendriss-Vermare, Nathalie; Salvetti, Anna; Klumpp, Klaus; Zoulim, Fabien; Heikenwalder, Mathias; Durantel, David; Lucifora, Julie

doi:10.6084/m9.figshare.24916839.v2

Poster EMDS Marion - final.pdf (4.65 MB)

Hepatitis B Virus-induced modulation of liver macrophage functions promotes hepatocyte infection

Version 2 2023-12-29, 13:37

Version 1 2023-12-29, 13:36

poster

posted on 2023-12-29, 13:37 authored by Faure-Dupuy S., marion delphinmarion delphin, ludovic aillot, Judith Fresquet, Romain Parent, Matthias Matter, Michel Rivoire, Nathalie Bendriss-Vermare, Anna Salvetti, Klaus Klumpp, Fabien Zoulim, Mathias Heikenwalder, David Durantel, Julie Lucifora

Liver macrophages are the largest macrophages population, acting as the main liver sentinel. They are involved in pathogen clearance and/or pathogenesis. Hepatitis B Virus (HBV) chronically infects more than 250 million people worldwide and is responsible for liver diseases. The severity of the disease may differ according to the HBV genotype (from A to J). Our aim was to characterize the interplay between HBV (genotypes C and D) and liver as well as infiltrating macrophages in order to understand how HBV may escape the immune system to establish and maintain its infection.