ppat.1006454.g005.tif (1.08 MB)
pUL11Fc modulates T cell proliferation in a dose dependent manner.
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posted on 2017-06-19, 17:45 authored by Jasmin Zischke, Panagiota Mamareli, Claudia Pokoyski, Ildar Gabaev, Sabine Buyny, Roland Jacobs, Christine S. Falk, Matthias Lochner, Tim Sparwasser, Thomas F. Schulz, Penelope C. Kay-FedorovPBMCs were either left unstimulated or stimulated with anti-CD3 (OKT3) together with the indicated concentrations of UL11Fc derived from HCMV strain (A) TB40 or (B) Merlin or with the Fc control protein. Single representative experiments from four (A) or two (B) replicates are shown; error bars show standard deviation of technical replicates.
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pUL 11 bindingCD 45 substrate LckTCRCD 45pUL 11CD 45 phosphatasePBMCIL -10 productionHCMV infectioncytomegalovirus glycoprotein pUL 11 actspUL 11. SupernatantspUL 11-induced changesT cell IL -10 secretionsignal strength influence T cell developmentT cell IL -10 secretion Human CytomegalovirusT cell proliferationT cells
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