pbio.3001230.s009.mov (18.74 MB)
SBF SEM Z stack of a HFD nephrocyte.
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posted on 2021-05-04, 17:51 authored by Aleksandra Lubojemska, M. Irina Stefana, Sebastian Sorge, Andrew P. Bailey, Lena Lampe, Azumi Yoshimura, Alana Burrell, Lucy Collinson, Alex P. GouldData were collected with a 0.2-μm step size and recorded at 20 fps. HFD, high-fat diet; SBF SEM, serial blockface scanning electron microscopy.
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CKDlipid droplet lipolysis counteractsRenal lipid dropletskidney disease Obesity-relatedrescue HFD-induced defectsnephrocyte lipid dropletslipid droplet resident enzyme ATGLHFD drives nephrocyte lipid uptakeendocytosiAdipose triglyceride lipaselipid dropletsmultiligand receptor Cubilinadipose triglyceride lipaseERdiglyceride acyltransferase 1DGATectopic accumulationlipid droplet triglyceride compartmentPGCperoxisome proliferator-activated r...
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