pone.0271707.s002.mp4 (5.53 MB)
Raw video file depicting a representative wild-type zebrafish recorded during the TEMR behavior test.
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posted on 2022-12-15, 18:55 authored by Madyson M. McCarthy, Makenna J. Hardy, Saylor E. Leising, Alex M. LaFollette, Erica S. Stewart, Amelia S. Cogan, Tanya Sanghal, Katie Matteo, Jonathon C. Reeck, Julia T. Oxford, Troy T. RohnTwo-minute videos were recorded on Motic MGT 101 Moticam recording device with an LED-60T-B light ring. After the start of the recording at time (T = 0), embryos were tapped lightly with a blunt probe every 15 seconds. See details in materials and methods section.
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reach statistical significancelabeling confocal microscopyincluding improper foldingenlarged cardiac cavitydeformed yolk sacapolipoprotein e4 leadsxlink "> 1tissue development supportdanio rerio apolipoprotein e4 (<observed following treatmentidentical treatment conditionsdiv >< pnovel pathophysiological functiondata demonstrating toxicity24 hours resulted17 kda amino151 >, exogenous treatmentzebrafish terminal apoe4 fragmentzebrafish (<exogenous treatmentapoe4 vivo vitro terminal fragmentear development1 immunoreactivityapoe4 proteintau pathologysub xmlnspresent studyposition 112nuclear localizationnegatively impactedmolecular underpinningsmodel systemincreased riskincreased phfincreased expressionhallmark featuresevoked responsesenhanced proteolysisdevelopmental abnormalitiescell toxicitybehavioral deficits>) allele
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