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Analysis of Crystal Size Dispersion Effects in a Continuous Coiled Tubular Crystallizer: Experiments and Modeling
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posted on 2018-01-24, 00:00 authored by Lukas Hohmann, Thorsten Greinert, Otto Mierka, Stefan Turek, Gerhard Schembecker, Evren Bayraktar, Kerstin Wohlgemuth, Norbert KockmannContinuous
processing gains importance in the fine chemical and
pharmaceutical industries where crystallization is an important downstream
operation. Seeded cooling crystallization of the l-alanine/water
system was investigated under similar conditions, i.e., temperature
interval, cooling rate, and seed material, both in a stirred batch
vessel and in a continuous plug flow crystallizer in the coiled flow
inverter (CFI) design with horizontal helical tube coils (ID = 4 mm)
and frequent 90° bends of the coils. Short-cut calculations based
on characteristic time scales and the Damköhler number allow
for comparing the batch and continuous crystallization processes.
The experimental results reveal crystal growth and growth rate dispersion
to be dominating on the product crystal size distribution (CSD). However,
at low flow rates of approximately 31 g min–1, a
moving sediment flow of the slurry was present in the CFI crystallizer,
resulting in further size dispersion effects. Elevated flow rates
of approximately 40 g min–1 resulted in a more homogeneous
suspension flow and a product CSD comparable to batch quality. Simulation
studies based on a population balance equation model strengthen the
hypothesis of the solid phase residence time distribution (RTDS) to be more spread in the moving sediment flow regime, leading
to a wider product CSD.
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Seeded cooling crystallizationRTDsediment flow regimegrowth rate dispersionplug flow crystallizerCrystal Size Dispersion Effectshelical tube coilssize dispersion effectsprocessing gains importancebatchElevated flow ratespopulation balance equation modelphase residence time distributionContinuous Coiled Tubular CrystallizerIDproduct CSDCFIproduct crystal size distribution
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