posted on 2022-12-21, 20:08authored byXiaolan Li, Jian Huang, Junhua Yun, Guoyan Zhang, Yufei Zhang, Mei Zhao, Hossain M. Zabed, Yuvaraj Ravikumar, Xianghui Qi
d-Arabitol, which is typically found in mushrooms,
lichens,
and higher fungi, might play an effective role in alleviating visceral
fat accumulation and insulin resistance particularly for its low calorie
and glycemic index. However, the regulatory mechanisms of d-arabitol for alleviating obesity and associated metabolic disorders
remain poorly understood. This study aimed to investigate and analyze
the underlying relationship between d-arabitol-mediated gut
microbiota and obesity. The results showed that d-arabitol
dramatically ameliorated body weight gain, fat accumulation, and insulin
resistance in HFD-fed rats. Likewise, d-arabitol remarkably
increased the relative abundance of the genera Blautia, Anaerostipes, and Phascolarctobacterium and decreased the genera Romboutsia and Clostridium_sensu_stricto_1. Furthermore, these alterations
in gut microflora increased SCFAs, which in turn indirectly promoted
AMPK-PGC-1α-related white adipose tissue (WAT) browning. Therefore, d-arabitol would have the potential to alleviate obesity through
the gut microbiota–SCFAs–WAT browning axis. It could
be considered as a sugar substitute for the obese population and diabetic
patients.