(top two panels) Representative average full scan mass spectra of derivatized DA and NE in brain tissue exhibiting the detection of their ions at m/z 258.1485 and 274.1435, respectively.

Washington-Hughes, Clorissa L.; Roy, Shubhrajit; Seneviratne, Herana Kamal; Karuppagounder, Senthilkumar S.; Morel, Yulemni; Jones, Jace W.; Zak, Alex; Xiao, Tong; Boronina, Tatiana N.; Cole, Robert N.; Bumpus, Namandjé N.; Chang, Christopher J.; Dawson, Ted M.; Lutsenko, Svetlana

doi:10.1371/journal.pgen.1010558.s006

pgen.1010558.s006.pdf (326.55 kB)

(top two panels) Representative average full scan mass spectra of derivatized DA and NE in brain tissue exhibiting the detection of their ions at m/z 258.1485 and 274.1435, respectively.

journal contribution

posted on 2023-01-10, 18:30 authored by Clorissa L. Washington-Hughes, Shubhrajit Roy, Herana Kamal Seneviratne, Senthilkumar S. Karuppagounder, Yulemni Morel, Jace W. Jones, Alex Zak, Tong Xiao, Tatiana N. Boronina, Robert N. Cole, Namandjé N. Bumpus, Christopher J. Chang, Ted M. Dawson, Svetlana Lutsenko

CHCA was used as the matrix. (bottom panels) In order to confirm the identities of derivatized DA and NE, collision-induced dissociation was carried out. From these experiments, derivatized DA exhibited fragment ions at m/z 122.0958 and 137.0591 corresponding to C8H12N+ and C8H8O2+, respectively. Similarly, derivatized NE yielded its fragment ions at m/z 122.0959 and 153.0540 corresponding to C8H12N+ and C8H8O3+, respectively.

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(top two panels) Representative average full scan mass spectra of derivatized DA and NE in brain tissue exhibiting the detection of their ions at m/z 258.1485 and 274.1435, respectively.

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