This preliminary report outlines clinical observations of two patients diagnosed with H63D Syndrome Type-3, also known as Oshtoran Syndrome. A 42-year-old woman from Malaysia and a 38-year-old man from Iran presented with complete remission of their obsessive thoughts caused by Oshtoran Syndrome. Alongside the administration of the Amitradicain formula, both patients received a high-dose corticosteroid treatment, resulting in the disappearance of all neuropsychiatric symptoms.